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The Journal of Neuroscience, October 18, 2006, 26(42):10624-10625; doi:10.1523/JNEUROSCI.4060-06.2006

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Mini-Review
mPar6{alpha} Controls Neuronal Migration

David J. Solecki, Eve-Ellen Govek, and Mary E. Hatten

Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021

Correspondence should be addressed to Mary E. Hatten, Laboratory of Developmental Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021. Email: hatten{at}rockefeller.edu

We review studies on the polarity of developing cerebellar granule, showing that the centrosome localizes to the pole of the neuron that extrudes the nascent axon, and the Rho GTPase Cdc42 (cell division cycle 42) activates the mPar6{alpha}/Par3 (Par for partitioning defective) complex to coordinate actin dynamics in the growth cone. Subsequently, mPar6{alpha} signaling controls the migration of immature granule neurons down the Bergmann glial fibers into the internal granule cell layer in which they establish synaptic connections.

Key words: neuronal polarity; cerebellum; granule cell; neurite extension; neuronal migration; mPar6{alpha}; Rho GTPases

Received Sept. 17, 2006; accepted Sept. 17, 2006.

Correspondence should be addressed to Mary E. Hatten, Laboratory of Developmental Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021. Email: hatten{at}rockefeller.edu






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