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The Journal of Neuroscience, October 25, 2006, 26(43):11131-11137; doi:10.1523/JNEUROSCI.2744-06.2006

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Behavioral/Systems/Cognitive
Auditory Brainstem Timing Predicts Cerebral Asymmetry for Speech

Daniel A. Abrams,¹ Trent Nicol,¹ Steven G. Zecker,¹ and Nina Kraus^1,2

¹Auditory Neuroscience Laboratory, Department of Communication Sciences, and ²Departments of Neurobiology and Physiology and Otolaryngology, Northwestern University, Evanston, Illinois 60208

Correspondence should be addressed to Daniel A. Abrams, 2240 Campus Drive, Evanston, IL 60208. Email: daabrams{at}northwestern.edu

The left hemisphere of the human cerebral cortex is dominant for processing rapid acoustic stimuli, including speech, and this specialized activity is preceded by processing in the auditory brainstem. It is not known to what extent the integrity of brainstem encoding of speech impacts patterns of asymmetry at cortex. Here, we demonstrate that the precision of temporal encoding of speech in auditory brainstem predicts cerebral asymmetry for speech sounds measured in a group of children spanning a range of language skills. Results provide strong evidence that timing deficits measured at the auditory brainstem negatively impact rapid acoustic processing by specialized structures of cortex, and demonstrate a delicate relationship between cortical activation patterns and the temporal integrity of cortical input.

Key words: auditory brainstem; auditory cortex; reading; dyslexia; cerebral asymmetry; speech

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Received June 27, 2006; revised Sept. 12, 2006; accepted Sept. 17, 2006.

Correspondence should be addressed to Daniel A. Abrams, 2240 Campus Drive, Evanston, IL 60208. Email: daabrams{at}northwestern.edu

This article has been cited by other articles:

				D. A. Abrams, T. Nicol, S. Zecker, and N. Kraus Right-Hemisphere Auditory Cortex Is Dominant for Coding Syllable Patterns in Speech J. Neurosci., April 9, 2008; 28(15): 3958 - 3965. [Abstract] [Full Text] [PDF]

				K. L. Johnson, T. G. Nicol, S. G. Zecker, and N. Kraus Auditory brainstem correlates of perceptual timing deficits. J. Cogn. Neurosci., March 1, 2007; 19(3): 376 - 385. [Abstract] [Full Text] [PDF]

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