 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, October 25, 2006, 26(43):11138-11147; doi:10.1523/JNEUROSCI.3550-06.2006
Previous Article | Next Article
Behavioral/Systems/Cognitive
Integration of Auditory and Visual Communication Information in the Primate Ventrolateral Prefrontal Cortex
Tadashi Sugihara,1 Mark D. Diltz,1 Bruno B. Averbeck,2,3 andLizabeth M. Romanski1 1Departments of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York 14642, 2Center for Visual Science, University of Rochester, Rochester, New York 14627-0270, and 3Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
Correspondence should be addressed to Dr. Lizabeth M. Romanski, Associate Professor, Department of Neurobiology and Anatomy, University of Rochester, Rochester, NY 14642. Email: Liz_romanski{at}urmc.rochester.edu
The integration of auditory and visual stimuli is crucial for recognizing objects, communicating effectively, and navigating through our complex world. Although the frontal lobes are involved in memory, communication, and language, there has been no evidence that the integration of communication information occurs at the single-cell level in the frontal lobes. Here, we show that neurons in the macaque ventrolateral prefrontal cortex (VLPFC) integrate audiovisual communication stimuli. The multisensory interactions included both enhancement and suppression of a predominantly auditory or a predominantly visual response, although multisensory suppression was the more common mode of response. The multisensory neurons were distributed across the VLPFC and within previously identified unimodal auditory and visual regions (O'Scalaidhe et al., 1997; Romanski and Goldman-Rakic, 2002). Thus, our study demonstrates, for the first time, that single prefrontal neurons integrate communication information from the auditory and visual domains, suggesting that these neurons are an important node in the cortical network responsible for communication.
Key words: vocalization; face; sensory integration; language; frontal lobe; cortex
Received May 9, 2006; revised Sept. 16, 2006; accepted Sept. 18, 2006.
Correspondence should be addressed to Dr. Lizabeth M. Romanski, Associate Professor, Department of Neurobiology and Anatomy, University of Rochester, Rochester, NY 14642. Email: Liz_romanski{at}urmc.rochester.edu
This article has been cited by other articles:
B. B. Averbeck, A. Battaglia-Mayer, C. Guglielmo, and R. Caminiti
Statistical Analysis of Parieto-Frontal Cognitive-Motor Networks
J Neurophysiol, September 1, 2009; 102(3): 1911 - 1920.
[Abstract] [Full Text] [PDF]
Y. Zahar, A. Reches, and Y. Gutfreund
Multisensory Enhancement in the Optic Tectum of the Barn Owl: Spike Count and Spike Timing
J Neurophysiol, May 1, 2009; 101(5): 2380 - 2394.
[Abstract] [Full Text] [PDF]
M. Gerbella, A. Belmalih, E. Borra, S. Rozzi, and G. Luppino
Cortical Connections of the Macaque Caudal Ventrolateral Prefrontal Areas 45A and 45B
Cereb Cortex, April 30, 2009; (2009) bhp087v1.
[Abstract] [Full Text] [PDF]
C. Chandrasekaran and A. A. Ghazanfar
Different Neural Frequency Bands Integrate Faces and Voices Differently in the Superior Temporal Sulcus
J Neurophysiol, February 1, 2009; 101(2): 773 - 788.
[Abstract] [Full Text] [PDF]
L. Proops, K. McComb, and D. Reby
From the Cover: Cross-modal individual recognition in domestic horses (Equus caballus)
PNAS, January 20, 2009; 106(3): 947 - 951.
[Abstract] [Full Text] [PDF]
B. L. Allman, R. E. Bittencourt-Navarrete, L. P. Keniston, A. E. Medina, M. Y. Wang, and M. A. Meredith
Do Cross-Modal Projections Always Result in Multisensory Integration?
Cereb Cortex, September 1, 2008; 18(9): 2066 - 2076.
[Abstract] [Full Text] [PDF]
R.R Thompson, P.S Dickinson, J.D Rose, K.A Dakin, G.M Civiello, A Segerdahl, and R Bartlett
Pheromones enhance somatosensory processing in newt brains through a vasotocin-dependent mechanism
Proc R Soc B, July 22, 2008; 275(1643): 1685 - 1693.
[Abstract] [Full Text] [PDF]
C. Kayser, C. I. Petkov, and N. K. Logothetis
Visual Modulation of Neurons in Auditory Cortex
Cereb Cortex, July 1, 2008; 18(7): 1560 - 1574.
[Abstract] [Full Text] [PDF]
B. N. Carriere, D. W. Royal, and M. T. Wallace
Spatial Heterogeneity of Cortical Receptive Fields and Its Impact on Multisensory Interactions
J Neurophysiol, May 1, 2008; 99(5): 2357 - 2368.
[Abstract] [Full Text] [PDF]
A. A. Ghazanfar, C. Chandrasekaran, and N. K. Logothetis
Interactions between the Superior Temporal Sulcus and Auditory Cortex Mediate Dynamic Face/Voice Integration in Rhesus Monkeys
J. Neurosci., April 23, 2008; 28(17): 4457 - 4469.
[Abstract] [Full Text] [PDF]
M. Awad, J. E. Warren, S. K. Scott, F. E. Turkheimer, and R. J. S. Wise
A Common System for the Comprehension and Production of Narrative Speech
J. Neurosci., October 24, 2007; 27(43): 11455 - 11464.
[Abstract] [Full Text] [PDF]
L. M. Romanski
Representation and Integration of Auditory and Visual Stimuli in the Primate Ventral Lateral Prefrontal Cortex
Cereb Cortex, September 1, 2007; 17(suppl_1): i61 - i69.
[Abstract] [Full Text] [PDF]
B. L. Allman and M. A. Meredith
Multisensory Processing in "Unimodal" Neurons: Cross-Modal Subthreshold Auditory Effects in Cat Extrastriate Visual Cortex
J Neurophysiol, July 1, 2007; 98(1): 545 - 549.
[Abstract] [Full Text] [PDF]
K. Kuraoka and K. Nakamura
Responses of Single Neurons in Monkey Amygdala to Facial and Vocal Emotions
J Neurophysiol, February 1, 2007; 97(2): 1379 - 1387.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|