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The Journal of Neuroscience, November 1, 2006, 26(44):11249-11252; doi:10.1523/JNEUROSCI.3543-06.2006

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Commentary
Three-Dimensional Reconstruction and Quantitative Study of a Pyramidal Cell of a Cajal Histological Preparation

Pablo García-López, Virginia García-Marín, and Miguel Freire

Museo Cajal, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain

Correspondence should be addressed to Virginia García-Marín, Museo Cajal, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Avenida Doctor Arce 37, 28002 Madrid, Spain. Email: vgmarin{at}cajal.csic.es

The year 2006 marks the centenary of the Nobel Prize for Physiology or Medicine awarded to Santiago Ramón y Cajal and Camilo Golgi. We commemorate this centenary with a three-dimensional reconstruction and a quantitative study of a pyramidal cell of a Cajal's histological preparation. This preparation is one of the 4529 histological preparations personally made by Ramón y Cajal and preserved in the Museum Cajal. The three-dimensional reconstruction of the neuron allows visualizing one important discovery of Ramón y Cajal that constitutes an active field of research in present-day neuroscience: dendritic spines.

Key words: Cajal; pyramidal cell; dendritic spines; filopodia; 3D reconstruction; Golgi method

Received Aug. 16, 2006; revised Sept. 25, 2006; accepted Sept. 25, 2006.

Correspondence should be addressed to Virginia García-Marín, Museo Cajal, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Avenida Doctor Arce 37, 28002 Madrid, Spain. Email: vgmarin{at}cajal.csic.es


Related articles in J. Neurosci.:

A Note of Appreciation for Reviewers and Editors
Gary Westbrook
J. Neurosci. 2007 27: ii. [Full Text]  





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