QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, November 1, 2006, 26(44):11397-11402; doi:10.1523/JNEUROSCI.0602-06.2006

This Article Full Text Full Text (PDF) Supplemental data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Gowing, G. Articles by Julien, J.-P. Search for Related Content PubMed PubMed Citation Articles by Gowing, G. Articles by Julien, J.-P.

 Previous Article  |  Next Article 

Neurobiology of Disease
Absence of Tumor Necrosis Factor- Does Not Affect Motor Neuron Disease Caused by Superoxide Dismutase 1 Mutations

Geneviève Gowing, Florence Dequen, Geneviève Soucy, and Jean-Pierre Julien

Laboratory of Molecular Endocrinology, Centre de Recherche du Centre Hospitalier de l'Université Laval Research Center, and Department of Anatomy and Physiology, Laval University 2705, Québec, Canada G1V 4G2

Correspondence should be addressed to Jean-Pierre Julien at the above address. E-mail: Email: jean-pierre.julien{at}crchul.ulaval.ca

An increase in the expression of the proinflammatory cytokine tumor necrosis factor (TNF-) has been observed in patients with amyotrophic lateral sclerosis (ALS) and in the mice models of the disease. TNF- is a potent activator of macrophages and microglia and, under certain conditions, can induce or exacerbate neuronal cell death. Here, we assessed the contribution of TNF- in motor neuron disease in mice overexpressing mutant superoxide dismutase 1 (SOD1) genes linked to familial ALS. This was accomplished by the generation of mice expressing SOD1^G37R or SOD1^G93A mutants in the context of TNF- gene knock out. Surprisingly, the absence of TNF- did not affect the lifespan or the extent of motor neuron loss in SOD1 transgenic mice. These results provide compelling evidence indicating that TNF- does not directly contribute to motor neuron degeneration caused by SOD1 mutations.

Key words: ALS; amyotrophic lateral sclerosis; degeneration; microglia; motoneuron; motor neuron; neuroinflammation; TNF-

---

Received Feb. 10, 2006; revised Sept. 22, 2006; accepted Sept. 25, 2006.

Correspondence should be addressed to Jean-Pierre Julien at the above address. E-mail: Email: jean-pierre.julien{at}crchul.ulaval.ca

This article has been cited by other articles:

				G. Gowing, T. Philips, B. Van Wijmeersch, J.-N. Audet, M. Dewil, L. Van Den Bosch, A. D. Billiau, W. Robberecht, and J.-P. Julien Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase J. Neurosci., October 8, 2008; 28(41): 10234 - 10244. [Abstract] [Full Text] [PDF]

				B. Barrette, M.-A. Hebert, M. Filali, K. Lafortune, N. Vallieres, G. Gowing, J.-P. Julien, and S. Lacroix Requirement of Myeloid Cells for Axon Regeneration J. Neurosci., September 17, 2008; 28(38): 9363 - 9376. [Abstract] [Full Text] [PDF]

				J. Kang and S. Rivest MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis J. Cell Biol., December 17, 2007; 179(6): 1219 - 1230. [Abstract] [Full Text] [PDF]

				S. L. Gibb, W. Boston-Howes, Z. S. Lavina, S. Gustincich, R. H. Brown Jr., P. Pasinelli, and D. Trotti A Caspase-3-cleaved Fragment of the Glial Glutamate Transporter EAAT2 Is Sumoylated and Targeted to Promyelocytic Leukemia Nuclear Bodies in Mutant SOD1-linked Amyotrophic Lateral Sclerosis J. Biol. Chem., November 2, 2007; 282(44): 32480 - 32490. [Abstract] [Full Text] [PDF]

				L. Lu, L. Zheng, L. Viera, E. Suswam, Y. Li, X. Li, A. G. Estevez, and P. H. King Mutant Cu/Zn-Superoxide Dismutase Associated with Amyotrophic Lateral Sclerosis Destabilizes Vascular Endothelial Growth Factor mRNA and Downregulates Its Expression J. Neurosci., July 25, 2007; 27(30): 7929 - 7938. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help