QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, November 8, 2006, 26(45):11644-11651; doi:10.1523/JNEUROSCI.3447-06.2006

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Peng, J. Articles by Andersen, J. K. Search for Related Content PubMed PubMed Citation Articles by Peng, J. Articles by Andersen, J. K.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Nigrostriatal Dopaminergic Neurodegeneration in the Weaver Mouse Is Mediated via Neuroinflammation and Alleviated by Minocycline Administration

Jun Peng,¹ Lin Xie,¹ Fang Feng Stevenson,¹ Simon Melov,¹ Donato A. Di Monte,² and Julie K. Andersen¹

¹Buck Institute for Age Research, Novato, California 94945, and ²Parkinson's Institute, Sunnyvale, California 94089

Correspondence should be addressed to Julie K. Andersen, Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945. Email: jandersen{at}buckinstitute.org

The murine mutant weaver (gene symbol, wv) mouse, which carries a mutation in the gene encoding the G-protein inwardly rectifying potassium channel Girk2, exhibits a diverse range of defects as a result of postnatal cell death in several different brain neuron subtypes. Loss of dopaminergic nigrostriatal neurons in the weaver, unlike cerebellar granule neuronal loss, is via a noncaspase-mediated mechanism. Here, we present data demonstrating that degeneration of midbrain dopaminergic neurons in weaver is mediated via neuroinflammation. Furthermore, in vivo administration of the anti-inflammatory agent minocycline attenuates nigrostriatal dopaminergic neurodegeneration. This has novel implications for the use of the weaver mouse as a model for Parkinson's disease, which has been associated with increased neuroinflammation.

Key words: weaver; dopaminergic midbrain neurons; caspase-independent cell death; microglial activation; minocycline; Parkinson

---

Received April 30, 2006; revised Sept. 21, 2006; accepted Sept. 22, 2006.

Correspondence should be addressed to Julie K. Andersen, Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945. Email: jandersen{at}buckinstitute.org

This article has been cited by other articles:

				T. Kielian, N. Esen, S. Liu, N. K. Phulwani, M. M. Syed, N. Phillips, K. Nishina, A. L. Cheung, J. D. Schwartzman, and J. J. Ruhe Minocycline Modulates Neuroinflammation Independently of Its Antimicrobial Activity in Staphylococcus aureus-Induced Brain Abscess Am. J. Pathol., October 1, 2007; 171(4): 1199 - 1214. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help