 |
||||
|
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, November 29, 2006, 26(48):12387-12396; doi:10.1523/JNEUROSCI.4316-06.2006
Previous Article | Next Article
Behavioral/Systems/Cognitive
Rethinking the Fear Circuit: The Central Nucleus of the Amygdala Is Required for the Acquisition, Consolidation, and Expression of Pavlovian Fear Conditioning
Ann E. Wilensky,1 * Glenn E. Schafe,2 * Morten P. Kristensen,1 andJoseph E. LeDoux1 1W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York, New York 10003, and 2Department of Psychology and Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520
Correspondence should be addressed to Dr. Joseph E. LeDoux, Center for Neural Science, New York University, Room 809, 4 Washington Place, New York, NY 10003. Email: ledoux{at}cns.nyu.edu
In the standard model of pavlovian fear learning, sensory input from neutral and aversive stimuli converge in the lateral nucleus of the amygdala (LA), in which alterations in synaptic transmission encode the association. During fear expression, the LA is thought to engage the central nucleus of the amygdala (CE), which serves as the principal output nucleus for the expression of conditioned fear responses. In the present study, we reexamined the roles of LA and CE. Specifically, we asked whether CE, like LA, might also be involved in fear learning and memory consolidation. Using functional inactivation methods, we first show that CE is involved not only in the expression but also the acquisition of fear conditioning. Next, we show that inhibition of protein synthesis in CE after training impairs fear memory consolidation. These findings indicate that CE is not only involved in fear expression but, like LA, is also involved in the learning and consolidation of pavlovian fear conditioning.
Key words: amygdala; central nucleus; consolidation; fear conditioning; muscimol; anisomycin
Received Nov. 7, 2003; accepted Oct. 3, 2006.
Correspondence should be addressed to Dr. Joseph E. LeDoux, Center for Neural Science, New York University, Room 809, 4 Washington Place, New York, NY 10003. Email: ledoux{at}cns.nyu.edu
Related articles in J. Neurosci.:
- The Central Amygdala Joins the Lateral Amygdala in the Fear Memory Party
- Stacie S. Miller and Gonzalo P. Urcelay
J. Neurosci. 2007 27: 2151-2152.[Full Text]
This article has been cited by other articles:
M. W. Pitts, C. Todorovic, T. Blank, and L. K. Takahashi
The Central Nucleus of the Amygdala and Corticotropin-Releasing Factor: Insights into Contextual Fear Memory
J. Neurosci., June 3, 2009; 29(22): 7379 - 7388.
[Abstract] [Full Text] [PDF]
J. Peters, P. W. Kalivas, and G. J. Quirk
Extinction circuits for fear and addiction overlap in prefrontal cortex
Learn. Mem., April 20, 2009; 16(5): 279 - 288.
[Abstract] [Full Text] [PDF]
G. Li, S. S. Nair, and G. J. Quirk
A Biologically Realistic Network Model of Acquisition and Extinction of Conditioned Fear Associations in Lateral Amygdala Neurons
J Neurophysiol, March 1, 2009; 101(3): 1629 - 1646.
[Abstract] [Full Text] [PDF]
S. Cole and G. P. McNally
Complementary roles for amygdala and periaqueductal gray in temporal-difference fear learning
Learn. Mem., December 30, 2008; 16(1): 1 - 7.
[Abstract] [Full Text] [PDF]
F. Z. Nagy and D. Pare
Timing of Impulses From the Central Amygdala and Bed Nucleus of the Stria Terminalis to the Brain Stem
J Neurophysiol, December 1, 2008; 100(6): 3429 - 3436.
[Abstract] [Full Text] [PDF]
J. E. Ploski, V. J. Pierre, J. Smucny, K. Park, M. S. Monsey, K. A. Overeem, and G. E. Schafe
The Activity-Regulated Cytoskeletal-Associated Protein (Arc/Arg3.1) Is Required for Memory Consolidation of Pavlovian Fear Conditioning in the Lateral Amygdala
J. Neurosci., November 19, 2008; 28(47): 12383 - 12395.
[Abstract] [Full Text] [PDF]
V. Laurent and R. F. Westbrook
Distinct contributions of the basolateral amygdala and the medial prefrontal cortex to learning and relearning extinction of context conditioned fear
Learn. Mem., August 26, 2008; 15(9): 657 - 666.
[Abstract] [Full Text] [PDF]
B. J. Kolber, M. S. Roberts, M. P. Howell, D. F. Wozniak, M. S. Sands, and L. J. Muglia
Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning
PNAS, August 19, 2008; 105(33): 12004 - 12009.
[Abstract] [Full Text] [PDF]
J.-H. Han, A. P. Yiu, C. J. Cole, H.-L. Hsiang, R. L. Neve, and S. A. Josselyn
Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fear
Learn. Mem., May 30, 2008; 15(6): 443 - 453.
[Abstract] [Full Text] [PDF]
V. Laurent, A. R. Marchand, and R. F. Westbrook
The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear
Learn. Mem., May 5, 2008; 15(5): 304 - 314.
[Abstract] [Full Text] [PDF]
E. Knapska, K. Radwanska, T. Werka, and L. Kaczmarek
Functional Internal Complexity of Amygdala: Focus on Gene Activity Mapping After Behavioral Training and Drugs of Abuse
Physiol Rev, October 1, 2007; 87(4): 1113 - 1173.
[Abstract] [Full Text] [PDF]
J. M. Zimmerman, C. A. Rabinak, I. G. McLachlan, and S. Maren
The central nucleus of the amygdala is essential for acquiring and expressing conditional fear after overtraining
Learn. Mem., September 6, 2007; 14(9): 634 - 644.
[Abstract] [Full Text] [PDF]
M.-H. Monfils, K. K. Cowansage, and J. E. LeDoux
Brain-Derived Neurotrophic Factor: Linking Fear Learning to Memory Consolidation
Mol. Pharmacol., August 1, 2007; 72(2): 235 - 237.
[Abstract] [Full Text] [PDF]
S. S. Miller and G. P. Urcelay
The Central Amygdala Joins the Lateral Amygdala in the Fear Memory Party
J. Neurosci., February 28, 2007; 27(9): 2151 - 2152.
[Full Text] [PDF]
K. A. Corcoran and G. J. Quirk
Activity in Prelimbic Cortex Is Necessary for the Expression of Learned, But Not Innate, Fears
J. Neurosci., January 24, 2007; 27(4): 840 - 844.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|