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The Journal of Neuroscience, November 29, 2006, 26(48):12415-12426; doi:10.1523/JNEUROSCI.4118-06.2006

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Behavioral/Systems/Cognitive
Hippocampal Sharp Waves and Reactivation during Awake States Depend on Repeated Sequential Experience

Jadin C. Jackson,^1 * Adam Johnson,^2 * and A. David Redish³

¹Graduate Program in Neuroscience, ²Graduate Program in Neuroscience and Center for Cognitive Science, and ³Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455

Correspondence should be addressed to A. David Redish, Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455. Email: redish{at}ahc.umn.edu

Hippocampal firing patterns during behavior are reactivated during rest and subsequent slow-wave sleep. These reactivations occur during transient local field potential (LFP) events, termed sharp waves. Theories of hippocampal processing suggest that sharp waves arise from strengthened plasticity, and that the strengthened plasticity depends on repeated cofiring of pyramidal cells. We tested these predictions by recording neural ensembles and LFPs from rats running tasks requiring different levels of behavioral repetition. The number of sharp waves emitted increased during sessions with more regular behaviors. Reactivation became more similar to behavioral firing patterns across the session. This enhanced reactivation also depended on the regularity of the behavior. Additional studies in CA3 and CA1 found that the number of sharp waves emitted also increased in CA3 recordings as well as CA1, but that the time courses were different between the two structures.

Key words: hippocampus; sharp wave; local field potential; place cell; neural ensemble; CA3; CA1

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Received June 26, 2006; revised Oct. 23, 2006; accepted Oct. 24, 2006.

Correspondence should be addressed to A. David Redish, Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455. Email: redish{at}ahc.umn.edu

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