QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, December 6, 2006, 26(49):12656-12663; doi:10.1523/JNEUROSCI.4023-06.2006

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Ohyama, T. Articles by Mauk, M. D. Search for Related Content PubMed PubMed Citation Articles by Ohyama, T. Articles by Mauk, M. D.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Learning-Induced Plasticity in Deep Cerebellar Nucleus

Tatsuya Ohyama, William L. Nores, Javier F. Medina, Frank A. Riusech, and Michael D. Mauk

Keck Center for Neurobiology of Learning and Memory and Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, Texas 77030

Correspondence should be addressed to either of the following: Tatsuya Ohyama, Department of Neurobiology and Anatomy, 6431 Fannin Street, Medical School Building 7.628, Houston, TX 77030, Email: tatsuya.ohyama{at}uth.tmc.edu; or Michael D. Mauk at the above address, Email: Michael.D.Mauk{at}uth.tmc.edu

Evidence that cerebellar learning involves more than one site of plasticity comes from, in part, pavlovian eyelid conditioning, where disconnecting the cerebellar cortex abolishes one component of learning, response timing, but spares the expression of abnormally timed short-latency responses (SLRs). Here, we provide evidence that SLRs unmasked by cerebellar cortex lesions are mediated by an associative form of learning-induced plasticity in the anterior interpositus nucleus (AIN) of the cerebellum. We used pharmacological inactivation and/or electrical microstimulation of various sites afferent and efferent to the AIN to systematically eliminate alternative candidate sites of plasticity upstream or downstream from this structure. Collectively, the results suggest that cerebellar learning is mediated in part by plasticity in target nuclei downstream of the cerebellar cortex. These data demonstrate an instance in which an aspect of associative learning, SLRs, can be used as an index of plasticity at a specific site in the brain.

Key words: cerebellum; deep cerebellar nucleus; eyelid conditioning; learning; plasticity; timing

---

Received Sept. 14, 2006; revised Oct. 27, 2006; accepted Oct. 30, 2006.

Correspondence should be addressed to either of the following: Tatsuya Ohyama, Department of Neurobiology and Anatomy, 6431 Fannin Street, Medical School Building 7.628, Houston, TX 77030, Email: tatsuya.ohyama{at}uth.tmc.edu; or Michael D. Mauk at the above address, Email: Michael.D.Mauk{at}uth.tmc.edu

This article has been cited by other articles:

				H. E. Halverson, E. M. Hubbard, and J. H. Freeman Stimulation of the lateral geniculate, superior colliculus, or visual cortex is sufficient for eyeblink conditioning in rats Learn. Mem., April 24, 2009; 16(5): 300 - 307. [Abstract] [Full Text] [PDF]

				B. E. Kalmbach, T. Ohyama, J. C. Kreider, F. Riusech, and M. D. Mauk Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioning Learn. Mem., January 7, 2009; 16(1): 86 - 95. [Abstract] [Full Text] [PDF]

				J. H. Freeman and M. M. Campolattaro Ontogenetic change in the auditory conditioned stimulus pathway for eyeblink conditioning Learn. Mem., October 30, 2008; 15(11): 823 - 828. [Abstract] [Full Text] [PDF]

				J. R. Pugh and I. M. Raman Mechanisms of Potentiation of Mossy Fiber EPSCs in the Cerebellar Nuclei by Coincident Synaptic Excitation and Inhibition J. Neurosci., October 15, 2008; 28(42): 10549 - 10560. [Abstract] [Full Text] [PDF]

				L. Roggeri, B. Rivieccio, P. Rossi, and E. D'Angelo Tactile Stimulation Evokes Long-Term Synaptic Plasticity in the Granular Layer of Cerebellum J. Neurosci., June 18, 2008; 28(25): 6354 - 6359. [Abstract] [Full Text] [PDF]

				J. H. Freeman, H. E. Halverson, and E. M. Hubbard Inferior colliculus lesions impair eyeblink conditioning in rats Learn. Mem., December 17, 2007; 14(12): 842 - 846. [Abstract] [Full Text] [PDF]

				N. Wada, Y. Kishimoto, D. Watanabe, M. Kano, T. Hirano, K. Funabiki, and S. Nakanishi Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission PNAS, October 16, 2007; 104(42): 16690 - 16695. [Abstract] [Full Text] [PDF]

				M. M. Campolattaro, H. E. Halverson, and J. H. Freeman Medial auditory thalamic stimulation as a conditioned stimulus for eyeblink conditioning in rats Learn. Mem., March 8, 2007; 14(3): 152 - 159. [Abstract] [Full Text] [PDF]

				D.-A. Jirenhed, F. Bengtsson, and G. Hesslow Acquisition, Extinction, and Reacquisition of a Cerebellar Cortical Memory Trace J. Neurosci., March 7, 2007; 27(10): 2493 - 2502. [Abstract] [Full Text] [PDF]

				M. W. Bagnall, R. J. Stevens, and S. du Lac Transgenic Mouse Lines Subdivide Medial Vestibular Nucleus Neurons into Discrete, Neurochemically Distinct Populations J. Neurosci., February 28, 2007; 27(9): 2318 - 2330. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help