 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, December 6, 2006, 26(49):12717-12726; doi:10.1523/JNEUROSCI.3502-06.2006
Previous Article | Next Article
Cellular/Molecular
Plasticity Compartments in Basal Dendrites of Neocortical Pyramidal Neurons
Urit Gordon, * Alon Polsky, * andJackie Schiller Department of Physiology, Technion Medical School, Haifa 31096, Israel
Correspondence should be addressed to Dr. Jackie Schiller, Technion Medical School, Bat-Galim, Haifa 31096, Israel. Email: jackie{at}tx.technion.ac.il
Synaptic plasticity rules widely determine how cortical networks develop and store information. Using confocal imaging and dual site focal synaptic stimulation, we show that basal dendrites, which receive the majority of synapses innervating neocortical pyramidal neurons, contain two compartments with respect to plasticity rules. Synapses innervating the proximal basal tree are easily modified when paired with the global activity of the neuron. In contrast, synapses innervating the distal basal tree fail to change in response to global suprathreshold activity or local dendritic spikes. These synapses can undergo long-term potentiation under unusual conditions when local NMDA spikes, which evoke large calcium transients, are paired with a "gating molecule," BDNF. Moreover, these synapses use a new temporal plasticity rule, which is an order of magnitude longer than spike timing dependent plasticity and prefers reversed presynaptic/postsynaptic activation order. The newly described plasticity compartmentalization of basal dendrites expands the networks plasticity rules and may support different learning and developmental functions.
Key words: dendrites; plasticity; LTP; dendritic spike; cortex; NMDA
Received Aug. 12, 2006; revised Oct. 20, 2006; accepted Oct. 20, 2006.
Correspondence should be addressed to Dr. Jackie Schiller, Technion Medical School, Bat-Galim, Haifa 31096, Israel. Email: jackie{at}tx.technion.ac.il
This article has been cited by other articles:
M. Zilberter, C. Holmgren, I. Shemer, G. Silberberg, S. Grillner, T. Harkany, and Y. Zilberter
Input Specificity and Dependence of Spike Timing-Dependent Plasticity on Preceding Postsynaptic Activity at Unitary Connections between Neocortical Layer 2/3 Pyramidal Cells
Cereb Cortex, October 1, 2009; 19(10): 2308 - 2320.
[Abstract] [Full Text] [PDF]
J. Hardie and N. Spruston
Synaptic Depolarization Is More Effective than Back-Propagating Action Potentials during Induction of Associative Long-Term Potentiation in Hippocampal Pyramidal Neurons
J. Neurosci., March 11, 2009; 29(10): 3233 - 3241.
[Abstract] [Full Text] [PDF]
C. D. Acker and S. D. Antic
Quantitative Assessment of the Distributions of Membrane Conductances Involved in Action Potential Backpropagation Along Basal Dendrites
J Neurophysiol, March 1, 2009; 101(3): 1524 - 1541.
[Abstract] [Full Text] [PDF]
C. E. J. Cheetham, M. S. L. Hammond, R. McFarlane, and G. T. Finnerty
Altered Sensory Experience Induces Targeted Rewiring of Local Excitatory Connections in Mature Neocortex
J. Neurosci., September 10, 2008; 28(37): 9249 - 9260.
[Abstract] [Full Text] [PDF]
G. Major, A. Polsky, W. Denk, J. Schiller, and D. W. Tank
Spatiotemporally Graded NMDA Spike/Plateau Potentials in Basal Dendrites of Neocortical Pyramidal Neurons
J Neurophysiol, May 1, 2008; 99(5): 2584 - 2601.
[Abstract] [Full Text] [PDF]
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser
Dendritic Excitability and Synaptic Plasticity
Physiol Rev, April 1, 2008; 88(2): 769 - 840.
[Abstract] [Full Text] [PDF]
J. Waters
Back to basals: do basal dendrites link plateau potentials and Up states?
J. Physiol., December 1, 2007; 585(2): 317 - 317.
[Full Text] [PDF]
A. Goel and H.-K. Lee
Persistence of Experience-Induced Homeostatic Synaptic Plasticity through Adulthood in Superficial Layers of Mouse Visual Cortex
J. Neurosci., June 20, 2007; 27(25): 6692 - 6700.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|