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The Journal of Neuroscience, December 13, 2006, 26(50):12861-12872; doi:10.1523/JNEUROSCI.4507-05.2006
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Cellular/Molecular
The Linear Computational Algorithm of Cerebellar Purkinje Cells
Joy T. Walter andKamran Khodakhah Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461
Correspondence should be addressed to Dr. Kamran Khodakhah, Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, KC 506, Bronx, NY 10461. Email: kkhodakh{at}aecom.yu.edu
The orchestration of simple motor tasks by the cerebellum results in coordinated movement and the maintenance of balance. The cerebellum integrates sensory and cortical information to generate the signals required for the coordinated execution of simple motor tasks. These signals originate in the firing rate of Purkinje cells, each of which integrates sensory and cortical information conveyed by granule cell synaptic inputs. Given the importance of the granule cell input–Purkinje cell output function for cerebellar computation, this algorithm was determined. Using several stimulation paradigms, including those that mimicked patterns of granule cell activity similar to those observed in vivo, we quantified the poststimulus maximum firing rate and number of extra spikes in response to granule cell synaptic input. Both of these parameters linearly encoded the strength of synaptic input when inhibitory synaptic transmission was blocked. This linear algorithm was independent of the location or temporal pattern of synaptic input. With inhibitory synaptic transmission intact, the maximum firing rate, but not the number of extra spikes, encoded the strength of granule cell synaptic input. Furthermore, the maximum firing rate of Purkinje cells linearly encoded the strength of synaptic input whether or not the activation of granule cells resulted in a pause in Purkinje cell firing. On the basis of the data presented, we propose that Purkinje cells encode the strength of granule cell synaptic input in their maximum firing rate with a linear algorithm.
Key words: activity; cerebellum; computational algorithm; granule cell; Purkinje neurons; synaptic communication
Received Oct. 20, 2005; revised Oct. 26, 2005; accepted Oct. 26, 2006.
Correspondence should be addressed to Dr. Kamran Khodakhah, Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, KC 506, Bronx, NY 10461. Email: kkhodakh{at}aecom.yu.edu
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