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The Journal of Neuroscience, December 13, 2006, 26(50):12956-12966; doi:10.1523/JNEUROSCI.4508-06.2006

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Development/Plasticity/Repair
GABA Regulates Dendritic Growth by Stabilizing Lamellipodia in Newly Generated Interneurons of the Olfactory Bulb

Eduardo Gascon,¹ Alexandre G. Dayer,^1,2 Marc-Olivier Sauvain,⁴ Gael Potter,¹ Benoit Jenny,¹ Mathias De Roo,¹ Eloisa Zgraggen,¹ Nicolas Demaurex,³ Dominique Muller,¹ and Jozsef Z. Kiss¹

Departments of ¹Neuroscience, ²Adult Psychiatry, and ³Cell Physiology and Metabolism, University of Geneva Medical School, CH-1211 Geneva, Switzerland, and ⁴School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland

Correspondence should be addressed to Jozsef Z. Kiss, Department of Neuroscience, University of Geneva Medical School, 1, Rue Michel Servet, CH-1211 Geneva, Switzerland. Email: jozsef.kiss{at}medecine.unige.ch

The initial formation and growth of dendrites is a critical step leading to the integration of newly generated neurons into postnatal functional networks. However, the cellular mechanisms and extracellular signals regulating this process remain mostly unknown. By directly observing newborn neurons derived from the subventricular zone in culture as well as in olfactory bulb slices, we show that ambient GABA acting through GABA_A receptors is essential for the temporal stability of lamellipodial protrusions in dendritic growth cones but did not interfere with filopodia dynamics. Furthermore, we provide direct evidence that ambient GABA is required for the proper initiation and elongation of dendrites by promoting the rapid stabilization of new dendritic segments after their extension. The effects of GABA on the initial formation of dendrites depend on depolarization and Ca²⁺ influx and are associated with a higher stability of microtubules. Together, our results indicate that ambient GABA is a key regulator of dendritic initiation in postnatally generated olfactory interneurons and offer a mechanism by which this neurotransmitter drives early dendritic growth.

Key words: dendritic development; GABA; neurogenesis; lamellipodia; subventricular zone; microtubule

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Received June 14, 2006; revised Nov. 2, 2006; accepted Nov. 2, 2006.

Correspondence should be addressed to Jozsef Z. Kiss, Department of Neuroscience, University of Geneva Medical School, 1, Rue Michel Servet, CH-1211 Geneva, Switzerland. Email: jozsef.kiss{at}medecine.unige.ch

This article has been cited by other articles:

				J.-C. Platel, K. A. Dave, and A. Bordey Control of neuroblast production and migration by converging GABA and glutamate signals in the postnatal forebrain J. Physiol., August 15, 2008; 586(16): 3739 - 3743. [Abstract] [Full Text] [PDF]

				E. Gascon, L. Vutskits, B. Jenny, P. Durbec, and J. Z. Kiss PSA-NCAM in postnatally generated immature neurons of the olfactory bulb: a crucial role in regulating p75 expression and cell survival Development, March 15, 2007; 134(6): 1181 - 1190. [Abstract] [Full Text] [PDF]

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