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The Journal of Neuroscience, December 20, 2006, 26(51):13363-13372; doi:10.1523/JNEUROSCI.4056-06.2006
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Behavioral/Systems/Cognitive
Cross-Whisker Adaptation of Neurons in the Rat Barrel Cortex
Yonatan Katz, * Jaime E. Heiss, * andIlan Lampl Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
Correspondence should be addressed to Dr. Ilan Lampl, Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel. Email: ilan.lampl{at}weizmann.ac.il
Neurons in the barrel cortex and the thalamus respond preferentially to stimulation of one whisker (the principal whisker) and weakly to several adjacent whiskers. Cortical neurons, unlike thalamic cells, gradually adapt to repeated whisker stimulations. Whether cortical adaptation is specific to the stimulated whisker is not known. The aim of this intracellular study was to determine whether the response of a cortical cell to stimulation of an adjacent whisker would be affected by previous adaptation induced by stimulation of the principal whisker and vice versa. Using a high-frequency stimulation that causes substantial adaptation in the cortex and much less adaptation in the thalamus, we show that cortical adaptation evoked by a train of stimuli applied to one whisker does not affect the synaptic response to subsequent stimulation of a neighboring whisker. Our data indicate that intrinsic mechanisms are not involved in cortical adaptation. Thalamic recordings obtained under the same conditions demonstrated that an adjacent whisker response was not generated in the thalamus, indicating that the observed whisker-specific adaptation results from diverging thalamic inputs or from cortical integration.
Key words: intracellular recording; in vivo; layer 4; receptive field; intracortical connections; VPM; vibrissa
Received Sept. 17, 2006; revised Nov. 15, 2006; accepted Nov. 17, 2006.
Correspondence should be addressed to Dr. Ilan Lampl, Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel. Email: ilan.lampl{at}weizmann.ac.il
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