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The Journal of Neuroscience, December 27, 2006, 26(52):13474-13484; doi:10.1523/JNEUROSCI.4333-06.2006

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Cellular/Molecular
The Endurance and Selectivity of Spatial Patterns of Long-Term Potentiation/Depression in Dendrites under Homeostatic Synaptic Plasticity

Ithai Rabinowitch and Idan Segev

Interdisciplinary Center for Neural Computation and the Department of Neurobiology, Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond Safra Campus, Givat Ram, Jerusalem, 91904, Israel

Correspondence should be addressed to Idan Segev, Interdisciplinary Center for Neural Computation and the Department of Neurobiology, Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond Safra Campus, Givat Ram, Jerusalem, 91904, Israel. Email: idan{at}lobster.ls.huji.ac.il

We investigated analytically and numerically the interplay between two opposing forms of synaptic plasticity: positive-feedback, long-term potentiation/depression (LTP/LTD), and negative-feedback, homeostatic synaptic plasticity (HSP). A detailed model of a CA1 pyramidal neuron, with numerous HSP-modifiable dendritic synapses, demonstrates that HSP may have an important role in selecting which spatial patterns of LTP/LTD are to last. Several measures are developed for predicting the net residual potentiation/depression after HSP from the initial spatial pattern of LTP/LTD. Under a local dendritic HSP mechanism, sparse patterns of LTP/LTD, which we show, using information theoretical tools, to have a significant impact on the output of the postsynaptic neuron, will persist. In contrast, spatially clustered patterns with a smaller impact on the output will diminish. A global somatic HSP mechanism, conversely, will favor distally occurring LTP/LTDs over proximal ones. Despite the negative-feedback nature of HSP, under both local and global HSP, numerous synaptic potentiations/depressions can persist. These experimentally testable results imply that HSP could be significantly involved in shaping the spatial distribution of synaptic weights in the dendrites and not just normalizing it, as is currently believed.

Key words: homeostatic plasticity; LTP; long-term potentiation; synaptic scaling; compartmental model; CA1 pyramidal; dendrite

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Received April 5, 2005; revised Nov. 5, 2006; accepted Nov. 6, 2006.

Correspondence should be addressed to Idan Segev, Interdisciplinary Center for Neural Computation and the Department of Neurobiology, Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond Safra Campus, Givat Ram, Jerusalem, 91904, Israel. Email: idan{at}lobster.ls.huji.ac.il

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