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The Journal of Neuroscience, December 27, 2006, 26(52):13531-13536; doi:10.1523/JNEUROSCI.4576-06.2006

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Brief Communications
Single-Cell Characterization of Retrograde Signaling by Brain-Derived Neurotrophic Factor

Jason P. Magby,¹ Caixia Bi,¹ Zhe-Yu Chen,² Francis S. Lee,² and Mark R. Plummer¹

¹Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, and ²Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10021

Correspondence should be addressed to Dr. Mark R. Plummer, Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, Busch Campus, 604 Allison Road, Piscataway, NJ 08854-8082. Email: mplummer{at}rci.rutgers.edu

Brain-derived neurotrophic factor (BDNF) is a key regulator of hippocampal synaptic plasticity in the developing and adult nervous system. It can be released from pyramidal neuron dendrites in an activity-dependent manner and has therefore been suggested to serve as a signal that provides the retrograde intercellular communication necessary for Hebbian plasticity and hippocampal-dependent learning. Although much has been learned about BDNF function by field stimulation of hippocampal neurons, it is not known whether moderate action potential-independent depolarization of single cells is capable of releasing sufficient BDNF to influence transmission at individual synapses. In this study, we show directly at the single-cell level that such modulation can occur. By using K-252a, anti-BDNF antibody, and interruption of regulated release, we confirm a model in which postsynaptic depolarization elicits calcium-dependent release of BDNF that diffuses retrogradely and enhances presynaptic transmitter release.

Key words: BDNF; neurosecretion; neurotrophin; synaptic communication; synaptic transmission; synaptogenesis

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Received June 22, 2006; revised Nov. 28, 2006; accepted Nov. 28, 2006.

Correspondence should be addressed to Dr. Mark R. Plummer, Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, Busch Campus, 604 Allison Road, Piscataway, NJ 08854-8082. Email: mplummer{at}rci.rutgers.edu

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