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The Journal of Neuroscience, February 15, 2006, 26(7):2000-2009; doi:10.1523/JNEUROSCI.3918-05.2006
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Cellular/Molecular
Glutamate Receptor Exocytosis and Spine Enlargement during Chemically Induced Long-Term Potentiation
Charles D. Kopec, * Bo Li, * Wei Wei, Jannic Boehm, andRoberto Malinow Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724
Correspondence should be addressed to Roberto Malinow, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724. Email: malinow{at}cshl.edu
The changes in synaptic morphology and receptor content that underlie neural plasticity are poorly understood. Here, we use a pH-sensitive green fluorescent protein to tag recombinant glutamate receptors and monitor their dynamics onto dendritic spine surfaces. We show that chemically induced long-term potentiation (chemLTP) drives robust exocytosis of AMPA receptors. In contrast, the same stimulus produces a small reduction of NMDA receptors from the spine surface. chemLTP produces similar modification of small and large spines. Interestingly, during chemLTP induction, spines increase in volume before accumulation of AMPA receptors on their surface, indicating that distinct mechanisms underlie changes in morphology and receptor content.
Key words: AMPA receptor; NMDA receptor; long-term potentiation; exocytosis; trafficking; two-photon microscopy
Received Sept. 15, 2005; revised Jan. 3, 2006; accepted Jan. 5, 2006.
Correspondence should be addressed to Roberto Malinow, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724. Email: malinow{at}cshl.edu
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