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The Journal of Neuroscience, March 7, 2007, 27(10):2704-2717; doi:10.1523/JNEUROSCI.2991-06.2007

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Development/Plasticity/Repair
ß1 Integrins Control the Formation of Cell Chains in the Adult Rostral Migratory Stream

Richard Belvindrah,¹ Sabine Hankel,¹ John Walker,² Bruce L. Patton,³ and Ulrich Müller¹

¹The Scripps Research Institute, Department of Cell Biology, Institute for Childhood and Neglected Disease, La Jolla, California 92037, ²Genomic Institute of the Novartis Research Foundation, San Diego, California 92121, and ³Oregon Health and Science University, Portland, Oregon 97239

Correspondence should be addressed to Ulrich Müller, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92073. Email: umueller{at}scripps.edu

The subventricular zone (SVZ) of the lateral ventricle is the major site of neurogenesis in the adult brain. Neuroblasts that are born in the SVZ migrate as chains along the rostral migratory stream (RMS) to the olfactory bulb. Little is known about the mechanisms that control interactions between neuroblasts during their migration. Here we show that migrating neuroblasts express ß1integrins and that the integrin ligand laminin is localized to cell chains. Using genetically modified mice and time-lapse video recordings of SVZ explants, we demonstrate that ß1 integrins and laminin promote the formation of cell chains. Laminin also induces the aggregation of purified neuroblasts. We conclude that the formation of cell chains in the RMS is controlled in part by ß1 integrins via binding to laminin. In addition, we provide evidence that ß1 class integrins are required for the maintenance of the glial tubes and that defects in the glial tubes lead to the ectopic migration of neuroblasts into the surrounding tissue.

Key words: ß1 integrins; SVZ; RMS; migration; laminin; CNS

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Received July 14, 2006; revised Jan. 26, 2007; accepted Jan. 29, 2007.

Correspondence should be addressed to Ulrich Müller, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92073. Email: umueller{at}scripps.edu

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