QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, March 14, 2007, 27(11):2948-2957; doi:10.1523/JNEUROSCI.5289-06.2007

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Barker, G. R. I. Articles by Warburton, E. C. Search for Related Content PubMed PubMed Citation Articles by Barker, G. R. I. Articles by Warburton, E. C.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Recognition Memory for Objects, Place, and Temporal Order: A Disconnection Analysis of the Role of the Medial Prefrontal Cortex and Perirhinal Cortex

Gareth R. I. Barker, Flora Bird, Victoria Alexander, and E. Clea Warburton

MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom

Correspondence should be addressed to Dr. E. C. Warburton, Department of Anatomy, University of Bristol, Medical School, University Walk, Bristol BS8 1TD, UK. Email: e.c.warburton{at}bristol.ac.uk

Recognition memory requires judgments of the previous occurrence of stimuli made on the basis of the relative familiarity of individual objects, or by integrating information concerning objects and location, or by using recency information. The present study examined the role of the medial prefrontal cortex (mPFC) and perirhinal cortex (PRH) in these distinct recognition memory processes using a series of behavioral tests: a novel object preference task, an object-in-place task, and a temporal order memory task. Also, a disconnection procedure was used to test whether these regions form components of an integrated system for recognition memory. Male DA rats received bilateral lesions in the PRH or mPFC or unilateral lesions placed in both cortices in either the same (PRH–mPFC IPSI) or contralateral (PRH–mPFC CONTRA) hemispheres. A fifth group underwent sham surgery (SHAM). In the object-in-place and temporal order memory tasks, the PRH, mPFC, and PRH–mPFC CONTRA groups were significantly impaired. However, performance in the novel object preference task was only impaired in the PRH group. No group was impaired in the object location task. These results demonstrate that the mPFC and PRH are crucial for object-in-place associational and recency discriminations, whereas the PRH but not the mPFC is important for the discrimination of novel and familiar individual objects. Importantly, these results provide direct support for the hypothesis that to make discriminations based on associational or recency information, both cortical regions operate within an integrated neural network for recognition memory.

Key words: familiarity discrimination; associational memory; recency memory; rat; perirhinal cortex; medial prefrontal cortex

---

Received Sept. 6, 2006; revised Jan. 19, 2007; accepted Jan. 22, 2007.

Correspondence should be addressed to Dr. E. C. Warburton, Department of Anatomy, University of Bristol, Medical School, University Walk, Bristol BS8 1TD, UK. Email: e.c.warburton{at}bristol.ac.uk

This article has been cited by other articles:

				L. Sui, J. Wang, and B.-M. Li Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex Learn. Mem., October 2, 2008; 15(10): 762 - 776. [Abstract] [Full Text] [PDF]

				I. Balderas, C. J. Rodriguez-Ortiz, P. Salgado-Tonda, J. Chavez-Hurtado, J. L. McGaugh, and F. Bermudez-Rattoni The consolidation of object and context recognition memory involve different regions of the temporal lobe Learn. Mem., August 21, 2008; 15(9): 618 - 624. [Abstract] [Full Text] [PDF]

				I. Lee and F. Solivan The roles of the medial prefrontal cortex and hippocampus in a spatial paired-association task Learn. Mem., May 5, 2008; 15(5): 357 - 367. [Abstract] [Full Text] [PDF]

				G. R. I. Barker and E. C. Warburton NMDA Receptor Plasticity in the Perirhinal and Prefrontal Cortices Is Crucial for the Acquisition of Long-Term Object-in-Place Associative Memory J. Neurosci., March 12, 2008; 28(11): 2837 - 2844. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help