QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, May 2, 2007, 27(18):4826-4831; doi:10.1523/JNEUROSCI.0400-07.2007

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Related articles in J. Neurosci. Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (12) Citing Articles via Google Scholar Google Scholar Articles by Seymour, B. Articles by Dolan, R. Search for Related Content PubMed PubMed Citation Articles by Seymour, B. Articles by Dolan, R.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Differential Encoding of Losses and Gains in the Human Striatum

Ben Seymour,¹ Nathaniel Daw,² Peter Dayan,² Tania Singer,^1,3 and Ray Dolan¹

¹Wellcome Trust Centre for Neuroimaging, UCL, London WC1N 3BG, United Kingdom, ²Gatsby Computational Neuroscience Unit, and ³Institute of Cognitive Neuroscience, London WC1N 3AR, United Kingdom

Correspondence should be addressed to Ben Seymour, Wellcome Trust Centre for Neuroimaging, UCL, 12 Queen Square, London WC1N 3BG, UK. Email: bseymour{at}fil.ion.ucl.ac.uk

Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues to outcomes that simultaneously incorporate the chance of financial reward and loss, we show that striatal activation reflects positively signed prediction errors for both. Furthermore, we show functional segregation within the striatum, with more anterior regions showing relative selectivity for rewards and more posterior regions for losses. These findings mirror the anteroposterior valence-specific gradient reported in rodents and endorse the role of the striatum in aversive motivational learning about financial losses, illustrating functional and anatomical consistencies with primary aversive outcomes such as pain.

Key words: basal ganglia; classical conditioning; reinforcement learning; neuroeconomics; opponent process; decision making

---

Received Jan. 29, 2007; revised Feb. 26, 2007; accepted March 18, 2007.

Correspondence should be addressed to Ben Seymour, Wellcome Trust Centre for Neuroimaging, UCL, 12 Queen Square, London WC1N 3BG, UK. Email: bseymour{at}fil.ion.ucl.ac.uk

Related articles in J. Neurosci.:

This Week in The Journal

J. Neurosci. 2007 27: i. [Full Text]  

This article has been cited by other articles:

				K. M. COX, H. J. AIZENSTEIN, and J. A. FIEZ Striatal outcome processing in healthy aging Cogn Affect Behav Neurosci, September 1, 2008; 8(3): 304 - 317. [Abstract] [PDF]

				M. X. COHEN Neurocomputational mechanisms of reinforcement-guided learning in humans: A review Cogn Affect Behav Neurosci, June 1, 2008; 8(2): 113 - 125. [Abstract] [PDF]

				S. Bray, A. Rangel, S. Shimojo, B. Balleine, and J. P O'Doherty The Neural Mechanisms Underlying the Influence of Pavlovian Cues on Human Decision Making J. Neurosci., May 28, 2008; 28(22): 5861 - 5866. [Abstract] [Full Text] [PDF]

				E. Z. Wheeler and L. K. Fellows The human ventromedial frontal lobe is critical for learning from negative feedback Brain, May 1, 2008; 131(5): 1323 - 1331. [Abstract] [Full Text] [PDF]

				C. A. Hutcherson, P. R. Goldin, W. Ramel, K. McRae, and J. J. Gross Attention and emotion influence the relationship between extraversion and neural response Soc Cogn Affect Neurosci, March 1, 2008; 3(1): 71 - 79. [Abstract] [Full Text] [PDF]

				C. Bellebaum, B. Koch, M. Schwarz, and I. Daum Focal basal ganglia lesions are associated with impairments in reward-based reversal learning Brain, March 1, 2008; 131(3): 829 - 841. [Abstract] [Full Text] [PDF]

				K. Fliessbach, B. Weber, P. Trautner, T. Dohmen, U. Sunde, C. E. Elger, and A. Falk Social Comparison Affects Reward-Related Brain Activity in the Human Ventral Striatum Science, November 23, 2007; 318(5854): 1305 - 1308. [Abstract] [Full Text] [PDF]

				D. T. Gilbert and T. D. Wilson Prospection: Experiencing the Future Science, September 7, 2007; 317(5843): 1351 - 1354. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help