QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, May 2, 2007, 27(18):4902-4909; doi:10.1523/JNEUROSCI.0717-07.2007

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Sieber, M. A. Articles by Birchmeier, C. Search for Related Content PubMed PubMed Citation Articles by Sieber, M. A. Articles by Birchmeier, C. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Lbx1 Acts as a Selector Gene in the Fate Determination of Somatosensory and Viscerosensory Relay Neurons in the Hindbrain

Martin A. Sieber,^1 * Robert Storm,^1 * Margaret Martinez-de-la-Torre,² Thomas Müller,¹ Hagen Wende,¹ Katja Reuter,¹ Elena Vasyutina,¹ and Carmen Birchmeier¹

¹Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany, and ²Department of Human Anatomy and Psychobiology, University of Murcia, 30100 Murcia, Spain

Correspondence should be addressed to Carmen Birchmeier, Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, Robert Rössle Strasse 10, 13125 Berlin, Germany. Email: cbirch{at}mdc-berlin.de

Distinct types of relay neurons in the hindbrain process somatosensory or viscerosensory information. How neurons choose between these two fates is unclear. We show here that the homeobox gene Lbx1 is essential for imposing a somatosensory fate on relay neurons in the hindbrain. In Lbx1 mutant mice, viscerosensory relay neurons are specified at the expense of somatosensory relay neurons. Thus Lbx1 expression distinguishes between the somatosensory or viscerosensory fate of relay neurons.

Key words: neuronal specification; homeobox gene; nucleus of the solitary tract; spinal trigeminal nucleus; genetic lineage tracing; development

---

Received May 11, 2005; revised March 8, 2007; accepted March 9, 2007.

Correspondence should be addressed to Carmen Birchmeier, Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, Robert Rössle Strasse 10, 13125 Berlin, Germany. Email: cbirch{at}mdc-berlin.de

This article has been cited by other articles:

				A. J. Barkovich, K. J. Millen, and W. B. Dobyns A developmental and genetic classification for midbrain-hindbrain malformations Brain, November 20, 2009; (2009) awp247v1. [Abstract] [Full Text] [PDF]

				M. Yu, G. A. Smolen, J. Zhang, B. Wittner, B. J. Schott, E. Brachtel, S. Ramaswamy, S. Maheswaran, and D. A. Haber A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression Genes & Dev., August 1, 2009; 23(15): 1737 - 1742. [Abstract] [Full Text] [PDF]

				R. Storm, J. Cholewa-Waclaw, K. Reuter, D. Brohl, M. Sieber, M. Treier, T. Muller, and C. Birchmeier The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei Development, January 15, 2009; 136(2): 295 - 305. [Abstract] [Full Text] [PDF]

				O. Hobert Gene Networks in Development and Evolution Special Feature Sackler Colloquium: Regulatory logic of neuronal diversity: Terminal selector genes and selector motifs PNAS, December 23, 2008; 105(51): 20067 - 20071. [Abstract] [Full Text] [PDF]

				S. Pagliardini, J. Ren, P. A. Gray, C. VanDunk, M. Gross, M. Goulding, and J. J. Greer Central Respiratory Rhythmogenesis Is Abnormal in Lbx1- Deficient Mice J. Neurosci., October 22, 2008; 28(43): 11030 - 11041. [Abstract] [Full Text] [PDF]

				Z. Liu, H. Li, X. Hu, L. Yu, H. Liu, R. Han, R. Colella, G. D. Mower, Y. Chen, and M. Qiu Control of Precerebellar Neuron Development by Olig3 bHLH Transcription Factor J. Neurosci., October 1, 2008; 28(40): 10124 - 10133. [Abstract] [Full Text] [PDF]

				P. A. Gray Transcription factors and the genetic organization of brain stem respiratory neurons J Appl Physiol, May 1, 2008; 104(5): 1513 - 1521. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help