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The Journal of Neuroscience, May 30, 2007, 27(22):6064-6067; doi:10.1523/JNEUROSCI.0627-07.2007

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Brief Communications
Rapid Synapse Elimination after Postsynaptic Protein Synthesis Inhibition In Vivo

Corey M. McCann, * Quyen T. Nguyen, * Humberto Santo Neto, and Jeff W. Lichtman

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138

Correspondence should be addressed to Jeff W. Lichtman at the above address.

To examine the role of retrograde signals on synaptic maintenance, we inhibited protein synthesis in individual postsynaptic cells in vivo while monitoring presynaptic terminals. Within 12 h, axon terminals begin to atrophy and withdraw from normal postsynaptic sites. Structural similarities between this process and naturally occurring synapse elimination suggest that short-lived target derived factors not only participate in synaptic maintenance in adults, but also regulate elimination of connections during development.

Key words: synaptic maintenance; trophic factors; neuromuscular junction; time lapse; synapse elimination; protein synthesis

Received Feb. 12, 2007; revised April 6, 2007; accepted April 24, 2007.

Correspondence should be addressed to Jeff W. Lichtman at the above address.




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J. Sebeo, K. Hsiao, O. Bozdagi, D. Dumitriu, Y. Ge, Q. Zhou, and D. L. Benson
Requirement for Protein Synthesis at Developing Synapses
J. Neurosci., August 5, 2009; 29(31): 9778 - 9793.
[Abstract] [Full Text] [PDF]


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