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The Journal of Neuroscience, June 20, 2007, 27(25):6692-6700; doi:10.1523/JNEUROSCI.5038-06.2007

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Development/Plasticity/Repair
Persistence of Experience-Induced Homeostatic Synaptic Plasticity through Adulthood in Superficial Layers of Mouse Visual Cortex

Anubhuthi Goel^1,2 and Hey-Kyoung Lee^1,2

¹Department of Biology, College of Chemical and Life Sciences, and ²Neuroscience and Cognitive Science Program, University of Maryland, College Park, Maryland 20742

Correspondence should be addressed to Dr. Hey-Kyoung Lee at the above address. Email: hlee21{at}umd.edu

It is well established that sensory cortices of animals can be modified by sensory experience, especially during a brief early critical period in development. Theoretical analyses indicate that there are two synaptic plasticity mechanisms required: input-specific synaptic modifications and global homeostatic mechanisms to provide stability to neural networks. Experience-dependent homeostatic synaptic plasticity mechanisms have subsequently been demonstrated in the visual cortex of juvenile animals. Here, we report that experience-dependent homeostatic synaptic plasticity persists through adulthood in the superficial layers of the mouse visual cortex. We found that 2 d of visual deprivation in the form of dark rearing is necessary and sufficient to cause an increase in AMPA receptor-mediated miniature EPSC amplitude in layer 2/3 neurons. This increase was rapidly reversed by 1 d of light exposure. This reversible change in synaptic strength persisted in adult mice past the critical period for ocular dominance plasticity, which is reported to end at 1 month of age in rodents. Interestingly, the mechanism of homeostatic synaptic modifications in 3-month-old mice differed from that in young mice (3 weeks old) in that the multiplicative nature of synaptic scaling is lost. Our results demonstrate that the superficial layers of adult mouse visual cortex retain the ability to undergo reversible experience-dependent homeostatic synaptic plasticity.

Key words: homeostatic plasticity; mEPSC; critical period; reversible modification; dark rearing; multiplicative

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Received Nov. 20, 2006; revised April 25, 2007; accepted May 16, 2007.

Correspondence should be addressed to Dr. Hey-Kyoung Lee at the above address. Email: hlee21{at}umd.edu

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