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The Journal of Neuroscience, July 18, 2007, 27(29):7786-7798; doi:10.1523/JNEUROSCI.1807-07.2007

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Development/Plasticity/Repair
Physiologically Distinct Temporal Cohorts of Cortical Interneurons Arise from Telencephalic Olig2-Expressing Precursors

Goichi Miyoshi,^1 * Simon J. B. Butt,^1 * Hirohide Takebayashi,² and Gord Fishell¹

¹Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, and ²Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki 444-8787, Japan

Correspondence should be addressed to Dr. Gord Fishell, Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016. Email: fishell{at}saturn.med.nyu.edu

Inhibitory GABAergic interneurons of the mouse neocortex are a highly heterogeneous population of neurons that originate from the ventral telencephalon and migrate tangentially up into the developing cortical plate. The majority of cortical interneurons arise from a transient embryonic structure known as the medial ganglionic eminence (MGE), but how the remarkable diversity is specified in this region is not known. We have taken a genetic fate mapping strategy to elucidate the temporal origins of cortical interneuron subtypes within the MGE. We used an inducible form of Cre under the regulation of Olig2, a basic helix-loop-helix transcription factor highly expressed in neural progenitors of the MGE. We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation.

Key words: cortex; electrophysiology; GABA; genetics; interneurons; transcription factor

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Received April 20, 2007; revised May 16, 2007; accepted June 9, 2007.

Correspondence should be addressed to Dr. Gord Fishell, Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016. Email: fishell{at}saturn.med.nyu.edu

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