QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, July 18, 2007, 27(29):7786-7798; doi:10.1523/JNEUROSCI.1807-07.2007

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (24) Citing Articles via Google Scholar Google Scholar Articles by Miyoshi, G. Articles by Fishell, G. Search for Related Content PubMed PubMed Citation Articles by Miyoshi, G. Articles by Fishell, G.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Physiologically Distinct Temporal Cohorts of Cortical Interneurons Arise from Telencephalic Olig2-Expressing Precursors

Goichi Miyoshi,^1 * Simon J. B. Butt,^1 * Hirohide Takebayashi,² and Gord Fishell¹

¹Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, and ²Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki 444-8787, Japan

Correspondence should be addressed to Dr. Gord Fishell, Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016. Email: fishell{at}saturn.med.nyu.edu

Inhibitory GABAergic interneurons of the mouse neocortex are a highly heterogeneous population of neurons that originate from the ventral telencephalon and migrate tangentially up into the developing cortical plate. The majority of cortical interneurons arise from a transient embryonic structure known as the medial ganglionic eminence (MGE), but how the remarkable diversity is specified in this region is not known. We have taken a genetic fate mapping strategy to elucidate the temporal origins of cortical interneuron subtypes within the MGE. We used an inducible form of Cre under the regulation of Olig2, a basic helix-loop-helix transcription factor highly expressed in neural progenitors of the MGE. We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation.

Key words: cortex; electrophysiology; GABA; genetics; interneurons; transcription factor

---

Received April 20, 2007; revised May 16, 2007; accepted June 9, 2007.

Correspondence should be addressed to Dr. Gord Fishell, Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016. Email: fishell{at}saturn.med.nyu.edu

This article has been cited by other articles:

				A. J. Canty, J. Dietze, M. Harvey, H. Enomoto, J. Milbrandt, and C. F. Ibanez Regionalized Loss of Parvalbumin Interneurons in the Cerebral Cortex of Mice with Deficits in GFR{alpha}1 Signaling J. Neurosci., August 26, 2009; 29(34): 10695 - 10705. [Abstract] [Full Text] [PDF]

				A. Mukhopadhyay, T. McGuire, C.-Y. Peng, and J. A. Kessler Differential effects of BMP signaling on parvalbumin and somatostatin interneuron differentiation Development, August 1, 2009; 136(15): 2633 - 2642. [Abstract] [Full Text] [PDF]

				D. M. Gelman, F. J. Martini, S. Nobrega-Pereira, A. Pierani, N. Kessaris, and O. Marin The Embryonic Preoptic Area Is a Novel Source of Cortical GABAergic Interneurons J. Neurosci., July 22, 2009; 29(29): 9380 - 9389. [Abstract] [Full Text] [PDF]

				L. Chung and S. D. Moore Cholecystokinin Excites Interneurons in Rat Basolateral Amygdala J Neurophysiol, July 1, 2009; 102(1): 272 - 284. [Abstract] [Full Text] [PDF]

				A. V. Zaitsev, N. V. Povysheva, G. Gonzalez-Burgos, D. Rotaru, K. N. Fish, L. S. Krimer, and D. A. Lewis Interneuron Diversity in Layers 2-3 of Monkey Prefrontal Cortex Cereb Cortex, July 1, 2009; 19(7): 1597 - 1615. [Abstract] [Full Text] [PDF]

				V. H. Sousa, G. Miyoshi, J. Hjerling-Leffler, T. Karayannis, and G. Fishell Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages Cereb Cortex, July 1, 2009; 19(suppl_1): i1 - i10. [Abstract] [Full Text] [PDF]

				J. E. Long, I. Cobos, G. B. Potter, and J. L. R. Rubenstein Dlx1 and Mash1 Transcription Factors Control MGE and CGE Patterning and Differentiation through Parallel and Overlapping Pathways Cereb Cortex, July 1, 2009; 19(suppl_1): i96 - i106. [Abstract] [Full Text] [PDF]

				R. S.E. Carney, L. A. Cocas, T. Hirata, K. Mansfield, and J. G. Corbin Differential Regulation of Telencephalic Pallial-Subpallial Boundary Patterning by Pax6 and Gsh2 Cereb Cortex, April 1, 2009; 19(4): 745 - 759. [Abstract] [Full Text] [PDF]

				M. Helmstaedter, B. Sakmann, and D. Feldmeyer The Relation between Dendritic Geometry, Electrical Excitability, and Axonal Projections of L2/3 Interneurons in Rat Barrel Cortex Cereb Cortex, April 1, 2009; 19(4): 938 - 950. [Abstract] [Full Text] [PDF]

				M. Helmstaedter, B. Sakmann, and D. Feldmeyer L2/3 Interneuron Groups Defined by Multiparameter Analysis of Axonal Projection, Dendritic Geometry, and Electrical Excitability Cereb Cortex, April 1, 2009; 19(4): 951 - 962. [Abstract] [Full Text] [PDF]

				D. H. Tanaka, M. Yanagida, Y. Zhu, S. Mikami, T. Nagasawa, J.-i. Miyazaki, Y. Yanagawa, K. Obata, and F. Murakami Random Walk Behavior of Migrating Cortical Interneurons in the Marginal Zone: Time-Lapse Analysis in Flat-Mount Cortex J. Neurosci., February 4, 2009; 29(5): 1300 - 1311. [Abstract] [Full Text] [PDF]

				L. Dimou, C. Simon, F. Kirchhoff, H. Takebayashi, and M. Gotz Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex J. Neurosci., October 8, 2008; 28(41): 10434 - 10442. [Abstract] [Full Text] [PDF]

				M. S. Brill, M. Snapyan, H. Wohlfrom, J. Ninkovic, M. Jawerka, G. S. Mastick, R. Ashery-Padan, A. Saghatelyan, B. Berninger, and M. Gotz A Dlx2- and Pax6-Dependent Transcriptional Code for Periglomerular Neuron Specification in the Adult Olfactory Bulb J. Neurosci., June 18, 2008; 28(25): 6439 - 6452. [Abstract] [Full Text] [PDF]

				S. J. B. Butt, I. Cobos, J. Golden, N. Kessaris, V. Pachnis, and S. Anderson Transcriptional Regulation of Cortical Interneuron Development J. Neurosci., October 31, 2007; 27(44): 11847 - 11850. [Full Text] [PDF]

				M. Fogarty, M. Grist, D. Gelman, O. Marin, V. Pachnis, and N. Kessaris Spatial Genetic Patterning of the Embryonic Neuroepithelium Generates GABAergic Interneuron Diversity in the Adult Cortex J. Neurosci., October 10, 2007; 27(41): 10935 - 10946. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help