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The Journal of Neuroscience, July 25, 2007, 27(30):7881-7887; doi:10.1523/JNEUROSCI.1740-07.2007

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Behavioral/Systems/Cognitive
Object Familiarity and Semantic Congruency Modulate Responses in Cortical Audiovisual Integration Areas

Grit Hein,^1,2,4 * Oliver Doehrmann,³ Notger G. Müller,^1,2 Jochen Kaiser,³ Lars Muckli,^2,5 and Marcus J. Naumer^2,3,5 *

¹Cognitive Neurology Unit, ²Brain Imaging Center, and ³Institute of Medical Psychology, Johann Wolfgang Goethe-University, D-60528 Frankfurt am Main, Germany, ⁴Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, and ⁵Department of Neurophysiology, Max Planck Institute for Brain Research, D-60528 Frankfurt am Main, Germany

Correspondence should be addressed to Dr. Marcus J. Naumer, Institut für Medizinische Psychologie, Johann Wolfgang Goethe-Universität, Heinrich-Hoffmann-Strasse 10 (Haus 93C), D-60528 Frankfurt am Main, Germany. Email: M.J.Naumer{at}med.uni-frankfurt.de

The cortical integration of auditory and visual features is crucial for efficient object recognition. Previous studies have shown that audiovisual (AV) integration is affected by where and when auditory and visual features occur. However, because relatively little is known about the impact of what is integrated, we here investigated the impact of semantic congruency and object familiarity on the neural correlates of AV integration. We used functional magnetic resonance imaging to identify regions involved in the integration of both (congruent and incongruent) familiar animal sounds and images and of arbitrary combinations of unfamiliar artificial sounds and object images. Unfamiliar object images and sounds were integrated in the inferior frontal cortex (IFC), possibly reflecting learning of novel AV associations. Integration of familiar, but semantically incongruent combinations also correlated with IFC activation and additionally involved the posterior superior temporal sulcus (pSTS). For highly familiar semantically congruent AV pairings, we again found AV integration effects in pSTS and additionally in superior temporal gyrus. These findings demonstrate that the neural correlates of object-related AV integration reflect both semantic congruency and familiarity of the integrated sounds and images.

Key words: multisensory integration; cross-modal; object recognition; familiarity; semantic congruency; functional magnetic resonance imaging; fMRI

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Received Jan. 26, 2007; accepted May 6, 2007.

Correspondence should be addressed to Dr. Marcus J. Naumer, Institut für Medizinische Psychologie, Johann Wolfgang Goethe-Universität, Heinrich-Hoffmann-Strasse 10 (Haus 93C), D-60528 Frankfurt am Main, Germany. Email: M.J.Naumer{at}med.uni-frankfurt.de

This article has been cited by other articles:

				M. J. Naumer, O. Doehrmann, N. G. Muller, L. Muckli, J. Kaiser, and G. Hein Cortical Plasticity of Audio-Visual Object Representations Cereb Cortex, July 1, 2009; 19(7): 1641 - 1653. [Abstract] [Full Text] [PDF]

				H.-D. Xiang, H. M. Fonteijn, D. G. Norris, and P. Hagoort Topographical Functional Connectivity Pattern in the Perisylvian Language Networks Cereb Cortex, June 22, 2009; (2009) bhp119v1. [Abstract] [Full Text] [PDF]

				J. Hocking and C. J. Price The Role of the Posterior Superior Temporal Sulcus in Audiovisual Processing Cereb Cortex, October 1, 2008; 18(10): 2439 - 2449. [Abstract] [Full Text] [PDF]

				G. F. Alpert, G. Hein, N. Tsai, M. J. Naumer, and R. T. Knight Temporal Characteristics of Audiovisual Information Processing J. Neurosci., May 14, 2008; 28(20): 5344 - 5349. [Abstract] [Full Text] [PDF]

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