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The Journal of Neuroscience, July 25, 2007, 27(30):8023-8030; doi:10.1523/JNEUROSCI.0789-07.2007

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Behavioral/Systems/Cognitive
Transcranial Magnetic Stimulation Reveals Two Cortical Pathways for Visual Body Processing

Cosimo Urgesi,¹ Beatriz Calvo-Merino,² Patrick Haggard,² and Salvatore M. Aglioti^3,4

¹Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) "E. Medea," Polo Friuli Venezia Giulia, I-33078 San Vito al Tagliamento, Pordenone, Italy, ²Institute of Cognitive Neuroscience and Psychology Department, University College London, London WC1N 3AR, United Kingdom, ³Dipartimento di Psicologia, Università di Roma "La Sapienza," I-00185 Rome, Italy, and ⁴IRCCS Fondazione Santa Lucia, I-00179 Rome, Italy

Correspondence should be addressed to either Dr. Salvatore M. Aglioti or Dr. Cosimo Urgesi, Department of Psychology, University of Rome "La Sapienza," Via dei Marsi 78, I-00185 Rome, Italy. Email: salvatoremaria.aglioti{at}uniroma1.it or Email: cosimo.urgesi{at}uniud.it

Visual recognition of human bodies is more difficult for upside down than upright presentations. This body inversion effect implies that body perception relies on configural rather than local processing. Although neuroimaging studies indicate that the visual processing of human bodies engages a large fronto-temporo-parietal network, information about the neural underpinnings of configural body processing is meager. Here, we used repetitive transcranial magnetic stimulation (rTMS) to study the causal role of premotor, visual, and parietal areas in configural processing of human bodies. Eighteen participants performed a delayed matching-to-sample task with upright or inverted static body postures. Event-related, dual-pulse rTMS was applied 150 ms after the sample stimulus onset, over left ventral premotor cortex (vPMc), right extrastriate body area (EBA), and right superior parietal lobe (SPL) and, as a control site, over the right primary visual cortex (V1). Interfering stimulation of vPMc significantly reduced accuracy of matching judgments for upright bodies. In contrast, EBA rTMS significantly reduced accuracy for inverted but not for upright bodies. Furthermore, a significant body inversion effect was observed after interfering stimulation of EBA and V1 but not of vPMc and SPL. These results demonstrate an active contribution of the fronto-parietal mirror network to configural processing of bodies and suggest a novel, embodied aspect of visual perception. In contrast, the local processing of the body, possibly based on the form of individual body parts instead of on the whole body unit, appears to depend on EBA. Therefore, we propose two distinct cortical routes for the visual processing of human bodies.

Key words: body perception; body inversion effect; extrastriate body area; premotor cortex; mirror neurons; repetitive transcranial magnetic stimulation

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Received Feb. 21, 2007; revised May 17, 2007; accepted June 13, 2007.

Correspondence should be addressed to either Dr. Salvatore M. Aglioti or Dr. Cosimo Urgesi, Department of Psychology, University of Rome "La Sapienza," Via dei Marsi 78, I-00185 Rome, Italy. Email: salvatoremaria.aglioti{at}uniroma1.it or Email: cosimo.urgesi{at}uniud.it

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