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The Journal of Neuroscience, July 25, 2007, 27(30):8053-8058; doi:10.1523/JNEUROSCI.0040-07.2007

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Brief Communications
Bilateral Spike-Triggered Average Effects in Arm and Shoulder Muscles from the Monkey Pontomedullary Reticular Formation

Adam G. Davidson,^1,3 Marc H. Schieber,⁴ and John A. Buford²

¹Neuroscience Graduate Studies Program and ²School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, and ³Department of Neurobiology and Anatomy and ⁴Departments of Neurology, Brain and Cognitive Science, Physical Medicine, and Rehabilitation, The Center for Visual Science and the Brain Injury Rehabilitation Program at St. Mary's Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

Correspondence should be addressed to Dr. Adam G. Davidson, University of Rochester Medical Center, Department of Neurobiology and Anatomy, 601 Elmwood Avenue, Box 603, Rochester, NY 14642. Email: adam_davidson{at}urmc.rochester.edu

Pontomedullary reticular formation (PMRF) neurons (309) were recorded simultaneously with electromyographic activity from arm and shoulder muscles in four monkeys performing arm-reaching tasks. Spike-triggered averages (SpikeTAs) were compiled for 292 neurons (3836 neuron–muscle pairs). Fourteen PMRF neurons located in a region ventral to the abducens nucleus produced 42 significant SpikeTA effects in arm and shoulder muscles. Of these 14 PMRF neurons, nine produced SpikeTA effects bilaterally. Overall, PMRF neurons facilitated ipsilateral flexors and contralateral extensors, while suppressing ipsilateral extensors and contralateral flexors. Spike- and stimulus-triggered averaging effects obtained from the same recording site were similar. These findings indicate that single PMRF neurons can directly influence movements of both upper limbs.

Key words: upper limb; brainstem; motor control; reticular; EMG; primate

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Received Jan. 5, 2007; revised June 19, 2007; accepted June 21, 2007.

Correspondence should be addressed to Dr. Adam G. Davidson, University of Rochester Medical Center, Department of Neurobiology and Anatomy, 601 Elmwood Avenue, Box 603, Rochester, NY 14642. Email: adam_davidson{at}urmc.rochester.edu

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				D. S. Soteropoulos and S. N. Baker Bilateral representation in the deep cerebellar nuclei J. Physiol., February 15, 2008; 586(4): 1117 - 1136. [Abstract] [Full Text] [PDF]

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