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The Journal of Neuroscience, August 1, 2007, 27(31):8442-8447; doi:10.1523/JNEUROSCI.0424-07.2007

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Brief Communications
The Transmembrane AMPA Receptor Regulatory Protein 4 Is a More Effective Modulator of AMPA Receptor Function than Stargazin (2)

Christoph Körber, Markus Werner, Sabine Kott, Zhan-Lu Ma, and Michael Hollmann

Department of Biochemistry I–Receptor Biochemistry, Ruhr University Bochum, D-44780 Bochum, Germany

Correspondence should be addressed to Prof. Dr. Michael Hollmann, Department of Biochemistry I–Receptor Biochemistry, Building NC, Room 6/171, Ruhr University Bochum, Universitätsstrasse 150, D-44780 Bochum, Germany. Email: michael.hollmann{at}rub.de

AMPA receptors mediate the majority of the fast excitatory synaptic transmission in the brain. A family of recently described auxiliary proteins, the transmembrane AMPA receptor regulatory proteins (TARPs) 2, 3, 4, and 8, have been shown to modulate the trafficking of receptors to the plasma membrane as well as electrophysiological key properties. Most studies published to date focus exclusively on 2 (stargazin), neglecting the other three members of the TARP family. Here, we analyzed the modulation of electrophysiological properties of AMPA receptors by 4 and compare it with 2, using heterologous coexpression in human embryonic kidney 293 cells. We show for the first time that 4, a previously poorly examined TARP, modulates the desensitization properties of AMPA receptors significantly stronger than 2 does. In contrast, other properties such as kainate efficacy and current–voltage relationships are modulated in a similar way by both of these TARPs. From these TARP-specific effects, we propose an interaction mechanism between AMPA receptors and TARPs and address the physiological relevance of 4 and its regulatory effects, particularly on AMPA receptor desensitization properties, to developmental and regulatory processes in the brain.

Key words: glutamate receptor; AMPA receptor; TARP; stargazin; 4; desensitization

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Received Jan. 30, 2007; revised June 25, 2007; accepted June 26, 2007.

Correspondence should be addressed to Prof. Dr. Michael Hollmann, Department of Biochemistry I–Receptor Biochemistry, Building NC, Room 6/171, Ruhr University Bochum, Universitätsstrasse 150, D-44780 Bochum, Germany. Email: michael.hollmann{at}rub.de

This article has been cited by other articles:

				C. Sager, J. Terhag, S. Kott, and M. Hollmann C-terminal Domains of Transmembrane {alpha}-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate (AMPA) Receptor Regulatory Proteins Not Only Facilitate Trafficking but Are Major Modulators of AMPA Receptor Function J. Biol. Chem., November 20, 2009; 284(47): 32413 - 32424. [Abstract] [Full Text] [PDF]

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