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The Journal of Neuroscience, August 29, 2007, 27(35):9400-9407; doi:10.1523/JNEUROSCI.2002-07.2007

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Development/Plasticity/Repair
Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling

Sebastian Jessberger, ^* Chunmei Zhao, ^* Nicolas Toni, Gregory D. Clemenson, Jr, Yan Li, and Fred H. Gage

Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037

Correspondence should be addressed to Fred H. Gage, Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037. Email: gage{at}salk.edu

Seizure activity within the hippocampal circuitry not only affects pre-existing structures, but also dramatically increases the number of newborn granule cells. A retroviral strategy was used to label dividing cells and their progeny in the adult dentate gyrus and to analyze the impact of epileptic activity on adult-generated cells labeled before or after seizures. We show that epileptic activity led to dramatic changes in the neuronal polarity, migration, and integration pattern of newborn granule cells, depending on the time of birth in relation to the epileptic insult. Aberrant neurons were stably integrated into the dentate circuitry, and the consequences on hippocampal neurogenesis were long lasting. The data presented characterized the consequences of seizure-associated plasticity on adult neurogenesis leading to long-term structural changes in the hippocampal circuitry that might represent a pivotal component of the epileptic disease process.

Key words: neurogenesis; hippocampus; seizure; basal dendrite; dendritic spine; maturation; epilepsy

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Received Jan. 10, 2007; revised July 12, 2007; accepted July 16, 2007.

Correspondence should be addressed to Fred H. Gage, Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037. Email: gage{at}salk.edu

This article has been cited by other articles:

				S. C. Danzer Postnatal and Adult Neurogenesis in the Development of Human Disease Neuroscientist, October 1, 2008; 14(5): 446 - 458. [Abstract] [PDF]

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