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The Journal of Neuroscience, September 5, 2007, 27(36):9648-9652; doi:10.1523/JNEUROSCI.2655-07.2007

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Brief Communications
Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex

Bin Jiang, Mario Treviño, and Alfredo Kirkwood

Mind/Brain Institute and Department of Neurosciences, Johns Hopkins University, Baltimore, Maryland 21218

Correspondence should be addressed to Alfredo Kirkwood, Mind/Brain Institute and Department of Neurosciences, Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218. Email: Kirkwood{at}jhu.edu

Visual deprivation affects the responses of layer IV cells more prominently during early postnatal development, whereas responses in layer II/III remain modifiable until later ages. We examined whether these laminar differences correlate with changes in long-term potentiation (LTP) and long-term depression (LTD) of the ascending pathways to layers IV and II/III in the mouse visual cortex. Our analysis revealed that LTP and LTD in layer IV principal cells is lost shortly after the eyes open, but persists in layers II/III beyond puberty. These results suggest that plasticity proceeds sequentially through cortical layers in a manner that parallels the flow of information during sensory processing.

Key words: critical period; layer IV; layer II/III; LTP; LTD; plasticity

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Received Sept. 30, 2006; revised July 23, 2007; accepted July 30, 2007.

Correspondence should be addressed to Alfredo Kirkwood, Mind/Brain Institute and Department of Neurosciences, Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218. Email: Kirkwood{at}jhu.edu

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