QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, September 5, 2007, 27(36):9682-9695; doi:10.1523/JNEUROSCI.2750-07.2007

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (47) Citing Articles via Google Scholar Google Scholar Articles by Flames, N. Articles by Marín, O. Search for Related Content PubMed PubMed Citation Articles by Flames, N. Articles by Marín, O. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Substance via MeSH Medline Plus Health Information Stem Cells

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Delineation of Multiple Subpallial Progenitor Domains by the Combinatorial Expression of Transcriptional Codes

Nuria Flames,¹ Ramón Pla,^1 * Diego M. Gelman,^1 * John L. R. Rubenstein,² Luis Puelles,^3,4 and Oscar Marín¹

¹Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain, ²Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, University of California at San Francisco, San Francisco, California 94143-2611, ³Departamento de Anatomía Humana y Psicobiología, Facultad de Medicina, Universidad de Murcia, 30100 Murcia, Spain, and ⁴U736, Centro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III, 30100 Murcia, Spain

Correspondence should be addressed to Dr. Oscar Marín, Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain. Email: o.marin{at}umh.es

The mammalian telencephalon is considered the most complex of all biological structures. It comprises a large number of functionally and morphologically distinct types of neurons that coordinately control most aspects of cognition and behavior. The subpallium, for example, not only gives rise to multiple neuronal types that form the basal ganglia and parts of the amygdala and septum but also is the origin of an astonishing diversity of cortical interneurons. Despite our detailed knowledge on the molecular, morphological, and physiological properties of most of these neuronal populations, the mechanisms underlying their generation are still poorly understood. Here, we comprehensively analyzed the expression patterns of several transcription factors in the ventricular zone of the developing subpallium in the mouse to generate a detailed molecular map of the different progenitor domains present in this region. Our study demonstrates that the ventricular zone of the mouse subpallium contains at least 18 domains that are uniquely defined by the combinatorial expression of several transcription factors. Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains.

Key words: telencephalon; subpallium; patterning; cell specification; interneuron diversity; cortex

---

Received Feb. 9, 2007; revised July 18, 2007; accepted July 19, 2007.

Correspondence should be addressed to Dr. Oscar Marín, Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain. Email: o.marin{at}umh.es

This article has been cited by other articles:

				A. Fragkouli, N. V. van Wijk, R. Lopes, N. Kessaris, and V. Pachnis LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons Development, November 15, 2009; 136(22): 3841 - 3851. [Abstract] [Full Text] [PDF]

				A. J. Canty, J. Dietze, M. Harvey, H. Enomoto, J. Milbrandt, and C. F. Ibanez Regionalized Loss of Parvalbumin Interneurons in the Cerebral Cortex of Mice with Deficits in GFR{alpha}1 Signaling J. Neurosci., August 26, 2009; 29(34): 10695 - 10705. [Abstract] [Full Text] [PDF]

				A. Mukhopadhyay, T. McGuire, C.-Y. Peng, and J. A. Kessler Differential effects of BMP signaling on parvalbumin and somatostatin interneuron differentiation Development, August 1, 2009; 136(15): 2633 - 2642. [Abstract] [Full Text] [PDF]

				D. M. Gelman, F. J. Martini, S. Nobrega-Pereira, A. Pierani, N. Kessaris, and O. Marin The Embryonic Preoptic Area Is a Novel Source of Cortical GABAergic Interneurons J. Neurosci., July 22, 2009; 29(29): 9380 - 9389. [Abstract] [Full Text] [PDF]

				V. H. Sousa, G. Miyoshi, J. Hjerling-Leffler, T. Karayannis, and G. Fishell Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages Cereb Cortex, July 1, 2009; 19(suppl_1): i1 - i10. [Abstract] [Full Text] [PDF]

				J. E. Long, I. Cobos, G. B. Potter, and J. L. R. Rubenstein Dlx1 and Mash1 Transcription Factors Control MGE and CGE Patterning and Differentiation through Parallel and Overlapping Pathways Cereb Cortex, July 1, 2009; 19(suppl_1): i96 - i106. [Abstract] [Full Text] [PDF]

				B. W. Okaty, M. N. Miller, K. Sugino, C. M. Hempel, and S. B. Nelson Transcriptional and Electrophysiological Maturation of Neocortical Fast-Spiking GABAergic Interneurons J. Neurosci., May 27, 2009; 29(21): 7040 - 7052. [Abstract] [Full Text] [PDF]

				R. S.E. Carney, L. A. Cocas, T. Hirata, K. Mansfield, and J. G. Corbin Differential Regulation of Telencephalic Pallial-Subpallial Boundary Patterning by Pax6 and Gsh2 Cereb Cortex, April 1, 2009; 19(4): 745 - 759. [Abstract] [Full Text] [PDF]

				D. H. Tanaka, M. Yanagida, Y. Zhu, S. Mikami, T. Nagasawa, J.-i. Miyazaki, Y. Yanagawa, K. Obata, and F. Murakami Random Walk Behavior of Migrating Cortical Interneurons in the Marginal Zone: Time-Lapse Analysis in Flat-Mount Cortex J. Neurosci., February 4, 2009; 29(5): 1300 - 1311. [Abstract] [Full Text] [PDF]

				S. Kanatani, M. Yozu, H. Tabata, and K. Nakajima COUP-TFII Is Preferentially Expressed in the Caudal Ganglionic Eminence and Is Involved in the Caudal Migratory Stream J. Neurosci., December 10, 2008; 28(50): 13582 - 13591. [Abstract] [Full Text] [PDF]

				R. Batista-Brito, R. Machold, C. Klein, and G. Fishell Gene Expression in Cortical Interneuron Precursors is Prescient of their Mature Function Cereb Cortex, October 1, 2008; 18(10): 2306 - 2317. [Abstract] [Full Text] [PDF]

				T. Du, Q. Xu, P. J. Ocbina, and S. A. Anderson NKX2.1 specifies cortical interneuron fate by activating Lhx6 Development, April 15, 2008; 135(8): 1559 - 1567. [Abstract] [Full Text] [PDF]

				Y. Elshatory and L. Gan The LIM-Homeobox Gene Islet-1 Is Required for the Development of Restricted Forebrain Cholinergic Neurons J. Neurosci., March 26, 2008; 28(13): 3291 - 3297. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help