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The Journal of Neuroscience, September 12, 2007, 27(37):9817-9823; doi:10.1523/JNEUROSCI.2707-07.2007

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Targeting Cre Recombinase to Specific Neuron Populations with Bacterial Artificial Chromosome Constructs

Shiaoching Gong,¹ Martin Doughty,¹ Carroll R. Harbaugh,⁴ Alexander Cummins,⁴ Mary E. Hatten,² Nathaniel Heintz,³ and Charles R. Gerfen⁴

¹Gene Expression Nervous System Atlas Project, ²Laboratory of Developmental Neurobiology, and ³Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, and ⁴Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892

Correspondence should be addressed to Charles R. Gerfen, Building 111, National Institutes of Health Animal Center, 16701 Elmer School Road, Dickerson, MD 20842. Email: gerfenc{at}mail.nih.gov

Transgenic mouse lines are characterized with Cre recombinase driven by promoters of CNS-specific genes using bacterial artificial chromosome (BAC) constructs. BAC-Cre constructs for 10 genes (Chat, Th, Slc6a4, Slc6a2, Etv1, Ntsr1, Drd2, Drd1, Pcp2, and Cmtm5) produced 14 lines with Cre expression in specific neuronal and glial populations in the brain. These Cre driver lines add functional utility to the >500 BAC-EGFP (enhanced green fluorescent protein) transgenic mouse lines that are part of the Gene Expression Nervous System Atlas Project.

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Received March 29, 2007; accepted July 10, 2007.

Correspondence should be addressed to Charles R. Gerfen, Building 111, National Institutes of Health Animal Center, 16701 Elmer School Road, Dickerson, MD 20842. Email: gerfenc{at}mail.nih.gov

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