QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, September 19, 2007, 27(38):10223-10229; doi:10.1523/JNEUROSCI.1505-07.2007

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Li, B. Articles by Freeman, R. D. Search for Related Content PubMed PubMed Citation Articles by Li, B. Articles by Freeman, R. D.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
High-Resolution Neurometabolic Coupling in the Lateral Geniculate Nucleus

Baowang Li and Ralph D. Freeman

Vision Science Group, School of Optometry, and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720-2020

Correspondence should be addressed to Dr. Ralph D. Freeman, 360 Minor Hall, University of California, Berkeley, Berkeley, CA 94720-2020. Email: freeman{at}neurovision.berkeley.edu

The relationships between neural and metabolic processes in activated brain regions are central to the interpretation of noninvasive imaging. To examine this relationship, we have used a specialized sensor to measure simultaneously tissue oxygen changes and neural activity in colocalized regions of the cat's lateral geniculate nucleus (LGN). Previous work with this sensor has shown that a decrease or increase in tissue oxygen can be elicited by selective control of the location and extent of neural activation in the LGN. In the current study, to evaluate the temporal integration and homogeneity of neurometabolic coupling, we have determined the relationship between multiunit extracellular neural activity and tissue oxygen responses to visual stimuli of various durations and contrasts. Our results show that the negative but not the positive oxygen response changes in an approximately linear manner with stimulus duration. The relationship between the negative oxygen response and neural activity is relatively constant with stimulus duration. Moreover, both negative and positive oxygen responses saturate at high stimulus contrast levels. Coupling between neural activity and negative oxygen responses is well described by a power law function. These results help elucidate differences between the initial negative and subsequent positive metabolic responses and may be directly relevant to questions concerning brain mapping with functional magnetic resonance imaging.

Key words: tissue oxygen; neural activity; linear and nonlinear; neurometabolic coupling; LGN; vision

---

Received April 4, 2007; revised July 9, 2007; accepted Aug. 1, 2007.

Correspondence should be addressed to Dr. Ralph D. Freeman, 360 Minor Hall, University of California, Berkeley, Berkeley, CA 94720-2020. Email: freeman{at}neurovision.berkeley.edu

This article has been cited by other articles:

				D. Ostwald, J. M. Lam, S. Li, and Z. Kourtzi Neural Coding of Global Form in the Human Visual Cortex J Neurophysiol, May 1, 2008; 99(5): 2456 - 2469. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help