QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, September 19, 2007, 27(38):10278-10288; doi:10.1523/JNEUROSCI.1602-07.2007

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Nie, T. Articles by Abel, T. Search for Related Content PubMed PubMed Citation Articles by Nie, T. Articles by Abel, T.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Genetic Disruption of Protein Kinase A Anchoring Reveals a Role for Compartmentalized Kinase Signaling in Theta-Burst Long-Term Potentiation and Spatial Memory

Ting Nie,^1 * Conor B. McDonough,^1 * Ted Huang,^1 * Peter V. Nguyen,² and Ted Abel¹

¹Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, and ²Departments of Physiology and Psychiatry, Centre for Neuroscience, University of Alberta School of Medicine, Edmonton, Alberta, Canada T6G 2H7

Correspondence should be addressed to Ted Abel at the above address. Email: abele{at}sas.upenn.edu

Studies of hippocampal long-term potentiation (LTP), a cellular model of memory storage, implicate cAMP-dependent protein kinase (PKA) in presynaptic and postsynaptic mechanisms of LTP. The anchoring of PKA to AKAPs (A kinase-anchoring proteins) creates compartmentalized pools of PKA, but the roles of presynaptically and postsynaptically anchored forms of PKA in late-phase LTP are unclear. In this study, we have created genetically modified mice that conditionally express Ht31, an inhibitor of PKA anchoring, to probe the roles of anchored PKA in hippocampal LTP and spatial memory. Our findings show that at hippocampal Schaffer collateral CA3–CA1 synapses, theta-burst LTP requires presynaptically anchored PKA. In addition, a pool of anchored PKA in hippocampal area CA3 is required for spatial memory. These findings reveal a novel and significant role for anchored PKA signaling in cellular mechanisms underlying memory storage.

Key words: cAMP-dependent protein kinase; A kinase-anchoring proteins; hippocampus; spatial memory; synaptic plasticity; LTP

---

Received April 10, 2007; revised Aug. 2, 2007; accepted Aug. 2, 2007.

Correspondence should be addressed to Ted Abel at the above address. Email: abele{at}sas.upenn.edu

This article has been cited by other articles:

				L. E. F. Almeida, P. D. Murray, H. R. Zielke, C. D. Roby, T. J. Kingsbury, and B. K. Krueger Autocrine Activation of Neuronal NMDA Receptors by Aspartate Mediates Dopamine- and cAMP-Induced CREB-Dependent Gene Transcription J. Neurosci., October 7, 2009; 29(40): 12702 - 12710. [Abstract] [Full Text] [PDF]

				J. Sebeo, K. Hsiao, O. Bozdagi, D. Dumitriu, Y. Ge, Q. Zhou, and D. L. Benson Requirement for Protein Synthesis at Developing Synapses J. Neurosci., August 5, 2009; 29(31): 9778 - 9793. [Abstract] [Full Text] [PDF]

				Z. Zheng and J. Keifer PKA Has a Critical Role in Synaptic Delivery of GluR1- and GluR4-Containing AMPARs During Initial Stages of Acquisition of In Vitro Classical Conditioning J Neurophysiol, May 1, 2009; 101(5): 2539 - 2549. [Abstract] [Full Text] [PDF]

				B. J. Tunquist, N. Hoshi, E. S. Guire, F. Zhang, K. Mullendorff, L. K. Langeberg, J. Raber, and J. D. Scott Loss of AKAP150 perturbs distinct neuronal processes in mice PNAS, August 26, 2008; 105(34): 12557 - 12562. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help