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The Journal of Neuroscience, October 3, 2007, 27(40):10870-10877; doi:10.1523/JNEUROSCI.3242-07.2007

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Behavioral/Systems/Cognitive
Hippocampal 4ß2 Nicotinic Acetylcholine Receptor Involvement in the Enhancing Effect of Acute Nicotine on Contextual Fear Conditioning

Jennifer A. Davis, ^* Justin W. Kenney, ^* and Thomas J. Gould

Department of Psychology, Neuroscience Program, Temple University, Philadelphia, Pennsylvania 19122

Correspondence should be addressed to Dr. Thomas J. Gould, Department of Psychology, Weiss Hall, Temple University, Philadelphia, PA 19122. Email: tgould{at}temple.edu

Nicotine is known to enhance learning and memory in hippocampus-dependent tasks such as contextual fear conditioning. The present study was designed to directly examine whether the hippocampus plays a role in mediating this enhancement and which nicotinic acetylcholine receptor (nAChR) subtypes localized to the hippocampus are critical for enhanced learning. Contextual fear conditioning consisted of two white noise conditioned stimuli presentations, each coterminating with a 2 s, 0.57 mA footshock separated by a 120 s intertrial interval. Nicotine (0.09, 0.18, and 0.35 µg per side) was bilaterally infused into the dorsal hippocampus before training and testing. Infusions of nicotine into the dorsal hippocampus produced a dose-dependent enhancement of contextual fear conditioning. To determine which nAChRs are critical to the enhancing effect of nicotine, the preferential 4ß2 nAChR antagonist, dihydro-ß-erythroidine (DHßE) (6.00 and 18.00 µg per side), or the preferential 7 nAChR antagonist, methyllycaconitine (MLA) (13.50 and 27.00 µg per side), was bilaterally infused into the dorsal hippocampus before systemic injections of nicotine (0.09 mg/kg). DHßE infusions dose-dependently blocked the enhancement of contextual fear conditioning by nicotine, whereas MLA infusions yielded an intermediate effect. In addition, neither DHßE nor MLA had an effect on contextual fear conditioning in the absence of systemic nicotine. The present results suggest a critical role for 4ß2 nAChRs in the dorsal hippocampus for mediating the enhancing effect of nicotine on contextual fear conditioning.

Key words: nicotine; hippocampus; nAChRs; addiction; learning; mouse

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Received July 17, 2007; revised Aug. 22, 2007; accepted Aug. 22, 2007.

Correspondence should be addressed to Dr. Thomas J. Gould, Department of Psychology, Weiss Hall, Temple University, Philadelphia, PA 19122. Email: tgould{at}temple.edu

This article has been cited by other articles:

				B. Tu, Z. Gu, J.-x. Shen, P. W. Lamb, and J. L. Yakel Characterization of a Nicotine-Sensitive Neuronal Population in Rat Entorhinal Cortex J. Neurosci., August 19, 2009; 29(33): 10436 - 10448. [Abstract] [Full Text] [PDF]

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