QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, October 10, 2007, 27(41):11132-11138; doi:10.1523/JNEUROSCI.2712-07.2007

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Thum, A. S. Articles by Tanimoto, H. Search for Related Content PubMed PubMed Citation Articles by Thum, A. S. Articles by Tanimoto, H.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Multiple Memory Traces for Olfactory Reward Learning in Drosophila

Andreas S. Thum,¹ Arnim Jenett,¹ Kei Ito,² Martin Heisenberg,¹ and Hiromu Tanimoto¹

¹Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany, and ²Institute of Molecular and Cellular Biosciences, University of Tokyo, 113-0032 Tokyo, Japan

Correspondence should be addressed to Hiromu Tanimoto at his present address: Max-Planck-Institut für Neurobiologie, Am Klopferspitz 18, D-82152 Martinsried, Germany. Email: hiromut{at}biozentrum.uni-wuerzburg.de or Email: hiromut{at}neuro.mpg.de

Physical traces underlying simple memories can be confined to a single group of cells in the brain. In the fly Drosophila melanogaster, the Kenyon cells of the mushroom bodies house traces for both appetitive and aversive odor memories. The adenylate cyclase protein, Rutabaga, has been shown to mediate both traces. Here, we show that, for appetitive learning, another group of cells can additionally accommodate a Rutabaga-dependent memory trace. Localized expression of rutabaga in either projection neurons, the first-order olfactory interneurons, or in Kenyon cells, the second-order interneurons, is sufficient for rescuing the mutant defect in appetitive short-term memory. Thus, appetitive learning may induce multiple memory traces in the first- and second-order olfactory interneurons using the same plasticity mechanism. In contrast, aversive odor memory of rutabaga is rescued selectively in the Kenyon cells, but not in the projection neurons. This difference in the organization of memory traces is consistent with the internal representation of reward and punishment.

Key words: learning; memory; insect; memory trace; olfaction; adenylate cyclase; Drosophila; short-term memory

---

Received Feb. 15, 2007; revised Aug. 29, 2007; accepted Aug. 29, 2007.

Correspondence should be addressed to Hiromu Tanimoto at his present address: Max-Planck-Institut für Neurobiologie, Am Klopferspitz 18, D-82152 Martinsried, Germany. Email: hiromut{at}biozentrum.uni-wuerzburg.de or Email: hiromut{at}neuro.mpg.de

This article has been cited by other articles:

				Y. Pan, Y. Zhou, C. Guo, H. Gong, Z. Gong, and L. Liu Differential roles of the fan-shaped body and the ellipsoid body in Drosophila visual pattern memory Learn. Mem., April 23, 2009; 16(5): 289 - 295. [Abstract] [Full Text] [PDF]

				K. Honjo and K. Furukubo-Tokunaga Distinctive Neuronal Networks and Biochemical Pathways for Appetitive and Aversive Memory in Drosophila Larvae J. Neurosci., January 21, 2009; 29(3): 852 - 862. [Abstract] [Full Text] [PDF]

				M. J. Krashes and S. Waddell Rapid Consolidation to a radish and Protein Synthesis-Dependent Long-Term Memory after Single-Session Appetitive Olfactory Conditioning in Drosophila J. Neurosci., March 19, 2008; 28(12): 3103 - 3113. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help