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The Journal of Neuroscience, October 24, 2007, 27(43):11624-11634; doi:10.1523/JNEUROSCI.2266-07.2007

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Cellular/Molecular
Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long-Term Depression That Is Affected in Fragile X Syndrome Mental Retardation

Lenora J. Volk, Brad E. Pfeiffer, Jay R. Gibson, and Kimberly M. Huber

Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390

Correspondence should be addressed to Kimberly Huber, Department of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9111. Email: Kimberly.Huber{at}UTSouthwestern.edu

Gq-coupled, M₁ muscarinic acetylcholine receptors (mAChRs) facilitate hippocampal learning, memory, and synaptic plasticity. M₁ mAChRs induce long-term synaptic depression (LTD), but little is known about the underlying mechanisms of mAChR-dependent LTD and its link to cognitive function. Here, we demonstrate that chemical activation of M₁ mAChRs induces LTD in hippocampal area CA1, which relies on rapid protein synthesis, as well as the extracellular signal-regulated kinase and mammalian target of rapamycin translational activation pathways. Synaptic stimulation of M₁ mAChRs, alone, or together with the Gq-coupled glutamate receptors (mGluRs), also results in protein synthesis-dependent LTD. New proteins maintain mAChR-dependent LTD through a persistent decrease in surface AMPA receptors. mAChRs stimulate translation of the RNA-binding protein, Fragile X mental retardation protein (FMRP) and FMRP target mRNAs. In mice without FMRP (Fmr1 knock-out), a model for human Fragile X syndrome mental retardation (FXS), both mGluR- and mAChR-dependent protein synthesis and LTD are affected. Our results reveal that multiple Gq-coupled receptors converge on a common protein synthesis-dependent LTD mechanism, which is aberrant in FXS. These findings suggest novel therapeutic strategies for FXS in the form of mAChR antagonists.

Key words: muscarinic acetylcholine; Gq coupled; metabotropic glutamate; hippocampus; Fragile X syndrome; long-term depression; protein synthesis

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Received May 17, 2007; revised Aug. 29, 2007; accepted Sept. 10, 2007.

Correspondence should be addressed to Kimberly Huber, Department of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9111. Email: Kimberly.Huber{at}UTSouthwestern.edu

This article has been cited by other articles:

				L. K. K. Pacey, S. P. Heximer, and D. R. Hampson Increased GABAB Receptor-Mediated Signaling Reduces the Susceptibility of Fragile X Knockout Mice to Audiogenic Seizures Mol. Pharmacol., July 1, 2009; 76(1): 18 - 24. [Abstract] [Full Text] [PDF]

				J. A. Ronesi and K. M. Huber Metabotropic Glutamate Receptors and Fragile X Mental Retardation Protein: Partners in Translational Regulation at the Synapse Sci. Signal., February 5, 2008; 1(5): pe6 - pe6. [Abstract] [Full Text] [PDF]

				J. A. Ronesi and K. M. Huber Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation J. Neurosci., January 9, 2008; 28(2): 543 - 547. [Abstract] [Full Text] [PDF]

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