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The Journal of Neuroscience, October 31, 2007, 27(44):11856-11859; doi:10.1523/JNEUROSCI.3624-07.2007

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Symposia and Mini-Symposia
Noncoding RNAs in the Brain

John S. Satterlee,1 Scott Barbee,2 Peng Jin,3 Anna Krichevsky,4 Sofie Salama,5 Gerhard Schratt,6 and Da-Yu Wu1

1Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, Bethesda, Maryland 20892, 2Department of Biological Sciences, University of Denver, Denver, Colorado 80208, 3Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, 4Neurology Center for Neurologic Diseases, Brigham and Women's Hospital Harvard Medical School, Boston, Massachusetts 02115, 5Center for Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California 95064, and 6Interdisciplinary Center for Neurosciences, University of Heidelberg, D-69120 Heidelberg, Germany

Correspondence should be addressed to John S. Satterlee, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, 6001 Executive Boulevard, Bethesda, MD 20892. Email: satterleej{at}nida.nih.gov

Cells transcribe thousands of RNAs that do not appear to encode proteins. The neuronal functions of these noncoding RNAs (ncRNAs) are for the most part not known, but specific ncRNAs have been shown to regulate dendritic spine development, neuronal fate specification and differentiation, and synaptic protein synthesis. ncRNAs have been implicated in a number of neuronal diseases including Tourette's syndrome and Fragile X syndrome. Future studies will likely identify additional neuronal functions for ncRNAs as well as roles for these molecules in other neuropsychiatric and neurodevelopmental disorders.

Key words: brain development; CREB; dendritic spine; development; differentiation; epigenetic; human forebrain development; learning and memory; neurogenesis; Purkinje neurons; RNA; synaptic plasticity

Received Aug. 9, 2007; revised Sept. 10, 2007; accepted Sept. 16, 2007.

Correspondence should be addressed to John S. Satterlee, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, 6001 Executive Boulevard, Bethesda, MD 20892. Email: satterleej{at}nida.nih.gov




This article has been cited by other articles:


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M. Ogorelkova, A. Navarro, F. Vivarelli, A. Ramirez-Soriano, and X. Estivill
Positive Selection and Gene Conversion Drive the Evolution of a Brain-Expressed snoRNAs Cluster
Mol. Biol. Evol., November 1, 2009; 26(11): 2563 - 2571.
[Abstract] [Full Text] [PDF]


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