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The Journal of Neuroscience, October 31, 2007, 27(44):11940-11948; doi:10.1523/JNEUROSCI.0900-07.2007

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Development/Plasticity/Repair
Changes of the EPSP Waveform Regulate the Temporal Window for Spike-Timing-Dependent Plasticity

Marco Fuenzalida, David Fernandez de Sevilla, and Washington Buño

Instituto Cajal, Consejo Superior de Investigaciones Científicas, 28002 Madrid, Spain

Correspondence should be addressed to Washington Buño, Instituto Cajal, Consejo Superior de Investigaciones Científicas, Avenida Doctor Arce 37, 28002 Madrid, Spain. Email: wbuno{at}cajal.csic.es

Using spike-timing-dependent plasticity (STDP) protocols that consist of pairing an EPSP and a postsynaptic backpropagating action potential (BAP), we investigated the contribution of the changes in EPSP waveform induced by the slow Ca²⁺-dependent K⁺-mediated afterhyperpolarization (sAHP) in the regulation of long-term potentiation (LTP). The "temporal window" between Schaffer collateral EPSPs and BAPs in CA1 pyramidal neurons required to induce LTP was narrowed by a reduction of the amplitude and decay time constant of the EPSP, which could be reversed with cyclothiazide. The EPSP changes were caused by the increased conductance induced by activation of the sAHP. Therefore, the EPSP waveform and its regulation by the sAHP are central in determining the duration of the temporal window for STDP, thus providing a possible dynamic regulatory mechanism for the encoding of cognitive processes.

Key words: temporal window; LTP regulation; increased conductance; EPSP profile; cyclothiazide; temporal coding

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Received Feb. 28, 2007; revised June 20, 2007; accepted July 31, 2007.

Correspondence should be addressed to Washington Buño, Instituto Cajal, Consejo Superior de Investigaciones Científicas, Avenida Doctor Arce 37, 28002 Madrid, Spain. Email: wbuno{at}cajal.csic.es

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Additional Relevant Work

Barrie Lancaster

J. Neurosci. Online, 14 Nov 2007 [Full text]

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