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The Journal of Neuroscience, November 7, 2007, 27(45):12176-12189; doi:10.1523/JNEUROSCI.3761-07.2007
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Behavioral/Systems/Cognitive
Neural Ensembles in CA3 Transiently Encode Paths Forward of the Animal at a Decision Point
Adam Johnson1 andA. David Redish2 1Center for Cognitive Sciences and 2Department of Neuroscience, Univeristy of Minnesota, Minneapolis, Minnesota 55455
Correspondence should be addressed to A. David Redish, Department of Neuroscience, Univeristy of Minnesota, 6-145 Jackson Hall, 321 Church St. Southeast Minneapolis, MN 55455. Email: redish{at}ahc.umn.edu
Neural ensembles were recorded from the CA3 region of rats running on T-based decision tasks. Examination of neural representations of space at fast time scales revealed a transient but repeatable phenomenon as rats made a decision: the location reconstructed from the neural ensemble swept forward, first down one path and then the other. Estimated representations were coherent and preferentially swept ahead of the animal rather than behind the animal, implying it represented future possibilities rather than recently traveled paths. Similar phenomena occurred at other important decisions (such as in recovery from an error). Local field potentials from these sites contained pronounced theta and gamma frequencies, but no sharp wave frequencies. Forward-shifted spatial representations were influenced by task demands and experience. These data suggest that the hippocampus does not represent space as a passive computation, but rather that hippocampal spatial processing is an active process likely regulated by cognitive mechanisms.
Key words: hippocampus; place cell; neural ensemble; vicarious trial; visual error; decision making; cognition
Received June 19, 2007; revised Sept. 12, 2007; accepted Sept. 18, 2007.
Correspondence should be addressed to A. David Redish, Department of Neuroscience, Univeristy of Minnesota, 6-145 Jackson Hall, 321 Church St. Southeast Minneapolis, MN 55455. Email: redish{at}ahc.umn.edu
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