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The Journal of Neuroscience, November 7, 2007, 27(45):12349-12357; doi:10.1523/JNEUROSCI.3127-07.2007

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Behavioral/Systems/Cognitive
Connected Corticospinal Sites Show Enhanced Tuning Similarity at the Onset of Voluntary Action

Yuval Yanai,¹ Nofya Adamit,¹ Ran Harel,^1,2 Zvi Israel,³ and Yifat Prut¹

¹The Hebrew University, Hadassah Medical School and the Interdisciplinary Center for Neural Computation, Jerusalem 91120, Israel, ²Department of Neurosurgery, Sheba Medical Center, Tel Aviv 52621, Israel, and ³Department of Neurosurgery, Hadassah Hospital, Jerusalem 91120, Israel

Correspondence should be addressed to Yifat Prut, Department of Physiology, The Hebrew University-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel. Email: yifatpr{at}ekmd.huji.ac.il

Corticospinal (CS) pathways provide the structural foundation for executing voluntary movements. Although the anatomy of these pathways is well explored, little is known about spinal decoding of parametric information transmitted via this route during voluntary movements. We addressed this question by simultaneously recording cortical and spinal activity in primates performing an isometric wrist task with multiple targets while measuring CS interactions. Single-pulse cortical stimulation effectively produced a short-latency (presumably monosynaptic) spinal response and thus revealed functionally connected CS sites. Spinal and cortical neurons recorded from connected CS sites showed alignment of directional-torque tuning that peaked at torque onset, consistent with the enhanced cortical drive active during this period. This increased tuning similarity was accompanied by an increased trial-to-trial covariability of firing. Whereas functional CS interactions were dynamic, the efficacy of cortical stimulation was unaffected by the motor state. These results suggest that around the onset of motor action there is a period of facilitated information transfer during which cortical command has greater efficacy in recruiting spinal neurons with matching tuning properties. Dynamic alignment of response properties may form the basis for a spinal readout mechanism of descending motor commands in which directional-torque is a parameter that is preserved across interacting CS sites.

Key words: motor cortex; spinal cord; corticospinal connectivity; directional tuning; noise correlation; motor control

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Received Jan. 26, 2007; revised Sept. 10, 2007; accepted Sept. 11, 2007.

Correspondence should be addressed to Yifat Prut, Department of Physiology, The Hebrew University-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel. Email: yifatpr{at}ekmd.huji.ac.il

This article has been cited by other articles:

				I. Asher, N. Zinger, Y. Yanai, Z. Israel, and Y. Prut Population-Based Corticospinal Interactions in Macaques Are Correlated with Visuomotor Processing Cereb Cortex, May 14, 2009; (2009) bhp095v1. [Abstract] [Full Text] [PDF]

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