QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, November 7, 2007, 27(45):12419-12429; doi:10.1523/JNEUROSCI.2015-07.2007

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Related articles in J. Neurosci. Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Wang, X.-b. Articles by Zhou, Q. Search for Related Content PubMed PubMed Citation Articles by Wang, X.-b. Articles by Zhou, Q.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Independent Expression of Synaptic and Morphological Plasticity Associated with Long-Term Depression

Xiao-bin Wang, Yunlei Yang, and Qiang Zhou

Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029

Correspondence should be addressed to Dr. Qiang Zhou, Department of Neurology, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1137, New York, NY 10029. Email: qiang.zhou{at}mssm.edu

Physiological and morphological alterations occur with long-term synaptic modifications, such as long-term potentiation (LTP) and long-term depression (LTD), but whether these two processes are independent or interactive is unclear. It is also unknown whether or how morphological modifications, like spine remodeling, may contribute to physiological modifications, such as trafficking of glutamate receptors which underlies, at least partially, the expression of LTP and LTD. In this study, we monitored spine size and synaptic responses simultaneously using combined two photon time-lapse imaging with patch-clamp recording in acute hippocampal slices. We show that spine shrinkage and LTD can occur independently of each other. We further show that changes in spine size are unrelated to trafficking of AMPA receptors (AMPARs) under various conditions: constitutive trafficking of AMPARs, insulin-induced internalization of AMPARs, or lateral movement of AMPARs to extrasynaptic sites. Induction of LTD of NMDA receptor-mediated responses (NMDAR-LTD) is associated with spine shrinkage. Nonetheless, NMDAR-LTD and spine shrinkage diverge in the downstream signaling events, and can occur independently of each other. Thus, spine shrinkage is not caused by or required for trafficking of glutamate receptors. In a broader sense, there is a clear dissociation between physiological and morphological expression of LTD. However, inhibition of actin depolymerization blocked the expression of LTD, suggesting that morphologically silent actin remodeling may be involved in the physiological expression of LTD and different subpopulations of actin filaments undergo changes during LTD.

Key words: dendritic spine; actin; long-term depression; synaptic plasticity; hippocampus; two-photon imaging

---

Received May 3, 2007; revised Aug. 31, 2007; accepted Sept. 20, 2007.

Correspondence should be addressed to Dr. Qiang Zhou, Department of Neurology, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1137, New York, NY 10029. Email: qiang.zhou{at}mssm.edu

Related articles in J. Neurosci.:

This Week in The Journal

J. Neurosci. 2007 27: i. [Full Text]  

This article has been cited by other articles:

				T. A. Blanpied, J. M. Kerr, and M. D. Ehlers Structural plasticity with preserved topology in the postsynaptic protein network PNAS, August 26, 2008; 105(34): 12587 - 12592. [Abstract] [Full Text] [PDF]

				Y. Yang, X.-b. Wang, M. Frerking, and Q. Zhou Spine Expansion and Stabilization Associated with Long-Term Potentiation J. Neurosci., May 28, 2008; 28(22): 5740 - 5751. [Abstract] [Full Text] [PDF]

				P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser Dendritic Excitability and Synaptic Plasticity Physiol Rev, April 1, 2008; 88(2): 769 - 840. [Abstract] [Full Text] [PDF]

				N. Bastrikova, G. A. Gardner, J. M. Reece, A. Jeromin, and S. M. Dudek Synapse elimination accompanies functional plasticity in hippocampal neurons PNAS, February 26, 2008; 105(8): 3123 - 3127. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help