QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, January 31, 2007, 27(5):1176-1183; doi:10.1523/JNEUROSCI.3745-06.2007

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Pasquereau, B. Articles by Boraud, T. Search for Related Content PubMed PubMed Citation Articles by Pasquereau, B. Articles by Boraud, T.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Shaping of Motor Responses by Incentive Values through the Basal Ganglia

Benjamin Pasquereau,^1,4 Agnes Nadjar,^1,4 David Arkadir,^1,3,4 Erwan Bezard,¹ Michel Goillandeau,¹ Bernard Bioulac,^1,2,4 Christian Eric Gross,^1,2,4 and Thomas Boraud^1,4

¹Basal Gang, Laboratoire de Neurophysiologie, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5227, Université Victor Segalen, 33076 Bordeaux, France, ²Centre Hospitalier Universitaire de Bordeaux, 33800 Bordeaux, France, ³Interdisciplinary Center for Neural Computation, The Hebrew University, Jerusalem 91905, Israel, and ⁴Laboratoire Franco-Israelien de Neurophysiologie et Neurophysique des Systemes, 33076 Bordeaux, France

Correspondence should be addressed to Thomas Boraud, Laboratoire de Neurophysiologie, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5227, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France. Email: tboraud{at}u-bordeaux2.fr

The striatum is a key neural interface for cognitive and motor information processing in which associations between reward value and visual stimulus can be used to modify motor commands. It can guide action–selection processes that occur farther downstream in the basal ganglia (BG) circuit, by encoding the reward value of an action. Here, we report on the study of simultaneously recorded neurons in the dorsal striatum (input stage of the BG) and the internal pallidum (output stage of the BG) in two monkeys performing a center-out motor task in which the visual targets were associated with different reward probabilities. We show that the tuning curves of motor-related neurons in both structures are modulated by the value of the action before movement initiation and during its execution. The representations of values associated with different actions change dynamically during the task in the internal globus pallidus, with a significant increase in the number of encoding neurons for the chosen target at the onset of movement. This report sheds additional light on the functional differences between the input and output structures of the BG and supports the assertion that the dorsal basal ganglia are involved in movement-related decision-making processes based on incentive values.

Key words: electrophysiology; striatum; globus pallidus; monkey; behavioral task; reward

---

Received Aug. 28, 2006; revised Dec. 26, 2006; accepted Dec. 27, 2006.

Correspondence should be addressed to Thomas Boraud, Laboratoire de Neurophysiologie, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5227, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France. Email: tboraud{at}u-bordeaux2.fr

This article has been cited by other articles:

				P. Gatev and T. Wichmann Interactions between Cortical Rhythms and Spiking Activity of Single Basal Ganglia Neurons in the Normal and Parkinsonian State Cereb Cortex, June 1, 2009; 19(6): 1330 - 1344. [Abstract] [Full Text] [PDF]

				N. D. Walsh and M. L. Phillips Interacting Outcome Retrieval, Anticipation, and Feedback Processes in the Human Brain Cereb Cortex, May 8, 2009; (2009) bhp098v1. [Abstract] [Full Text] [PDF]

				M. Joshua, A. Adler, B. Rosin, E. Vaadia, and H. Bergman Encoding of Probabilistic Rewarding and Aversive Events by Pallidal and Nigral Neurons J Neurophysiol, February 1, 2009; 101(2): 758 - 772. [Abstract] [Full Text] [PDF]

				J. Prodoehl, H. Yu, P. Wasson, D. M. Corcos, and D. E. Vaillancourt Effects of Visual and Auditory Feedback on Sensorimotor Circuits in the Basal Ganglia J Neurophysiol, June 1, 2008; 99(6): 3042 - 3051. [Abstract] [Full Text] [PDF]

				B. Lau and P. W. Glimcher Action and Outcome Encoding in the Primate Caudate Nucleus J. Neurosci., December 26, 2007; 27(52): 14502 - 14514. [Abstract] [Full Text] [PDF]

				J.-W. Sohn and D. Lee Order-Dependent Modulation of Directional Signals in the Supplementary and Presupplementary Motor Areas J. Neurosci., December 12, 2007; 27(50): 13655 - 13666. [Abstract] [Full Text] [PDF]

				Y. B. Kim, N. Huh, H. Lee, E. H. Baeg, D. Lee, and M. W. Jung Encoding of Action History in the Rat Ventral Striatum J Neurophysiol, December 1, 2007; 98(6): 3548 - 3556. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help