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The Journal of Neuroscience, December 19, 2007, 27(51):13991-13996; doi:10.1523/JNEUROSCI.3279-07.2007

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Brief Communications
The Adult Mouse Subependymal Zone Regenerates Efficiently in the Absence of Tenascin-C

Ilias Kazanis,¹ Aisha Belhadi,¹ Andreas Faissner,² and Charles ffrench-Constant¹

¹Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom, and ²Department of Cell Morphology and Molecular Neurobiology, Ruhr-University, D-44780 Bochum, Germany

Correspondence should be addressed to Ilias Kazanis, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK. Email: ik255{at}cam.ac.uk

The subependymal zone (SEZ) of the lateral ventricles of the adult mouse brain hosts neurogenesis from a neural stem cell population with the morphology of astrocytes (termed type-B cells). Tenascin-C is a large extracellular matrix glycoprotein present in the SEZ that has been shown to regulate the development of embryonic neural stem cells and the proliferation and migration of early postnatal neural precursors. Here we show that tenascin-C is produced by type-B cells and forms a layer between SEZ and the adjacent striatum. Tenascin-C deficiency resulted in minor structural differences in and around the SEZ. However, the numbers of neural stem cells and their progeny remained unaffected, as did their regeneration after depletion of mitotic cells using the antimitotic drug cytosine-β-D-arabinofuranoside. Our results reveal a remarkable ability of the adult neural stem cell niche to retain proper function even after the removal of major extracellular matrix molecules.

Key words: tenascin-C; extracellular matrix; adult neurogenesis; subependymal zone; stem cell; niche

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Received July 19, 2007; revised Oct. 26, 2007; accepted Nov. 5, 2007.

Correspondence should be addressed to Ilias Kazanis, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK. Email: ik255{at}cam.ac.uk

This article has been cited by other articles:

				I. Kazanis The subependymal zone neurogenic niche: a beating heart in the centre of the brain: How plastic is adult neurogenesis? Opportunities for therapy and questions to be addressed Brain, November 1, 2009; 132(11): 2909 - 2921. [Abstract] [Full Text] [PDF]

				H. B. Treloar, A. Ray, L. A. Dinglasan, M. Schachner, and C. A. Greer Tenascin-C Is an Inhibitory Boundary Molecule in the Developing Olfactory Bulb J. Neurosci., July 29, 2009; 29(30): 9405 - 9416. [Abstract] [Full Text] [PDF]

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