QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, February 28, 2007, 27(9):2349-2356; doi:10.1523/JNEUROSCI.5587-06.2007

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (18) Citing Articles via Google Scholar Google Scholar Articles by Seeley, W. W. Articles by Greicius, M. D. Search for Related Content PubMed PubMed Citation Articles by Seeley, W. W. Articles by Greicius, M. D.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control

William W. Seeley,¹ Vinod Menon,^2,3 Alan F. Schatzberg,² Jennifer Keller,² Gary H. Glover,^3,4 Heather Kenna,² Allan L. Reiss,^2,3 and Michael D. Greicius^2,5

¹Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, and ²Department of Psychiatry, ³Program in Neuroscience, ⁴Department of Radiology, and ⁵Department of Neurology, Stanford University School of Medicine, Stanford, California 94305

Correspondence should be addressed to Michael D. Greicius, Departments of Neurology and Neurological Sciences and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 300 Pasteur Drive, Room A343, Stanford, CA 94305-5235. Email: greicius{at}stanford.edu

Variations in neural circuitry, inherited or acquired, may underlie important individual differences in thought, feeling, and action patterns. Here, we used task-free connectivity analyses to isolate and characterize two distinct networks typically coactivated during functional MRI tasks. We identified a "salience network," anchored by dorsal anterior cingulate (dACC) and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an "executive-control network" that links dorsolateral frontal and parietal neocortices. These intrinsic connectivity networks showed dissociable correlations with functions measured outside the scanner. Prescan anxiety ratings correlated with intrinsic functional connectivity of the dACC node of the salience network, but with no region in the executive-control network, whereas executive task performance correlated with lateral parietal nodes of the executive-control network, but with no region in the salience network. Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior.

Key words: fMRI; functional connectivity; anterior cingulate; insula; salience; anxiety

---

Received Sept. 28, 2006; revised Jan. 19, 2007; accepted Jan. 22, 2007.

Correspondence should be addressed to Michael D. Greicius, Departments of Neurology and Neurological Sciences and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 300 Pasteur Drive, Room A343, Stanford, CA 94305-5235. Email: greicius{at}stanford.edu

This article has been cited by other articles:

				A.M. C. Kelly, A. Di Martino, L. Q. Uddin, Z. Shehzad, D. G. Gee, P. T. Reiss, D. S. Margulies, F. X. Castellanos, and M. P. Milham Development of Anterior Cingulate Functional Connectivity from Late Childhood to Early Adulthood Cereb Cortex, August 26, 2008; (2008) bhn117v2. [Abstract] [Full Text] [PDF]

				D. Sridharan, D. J. Levitin, and V. Menon A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks PNAS, August 26, 2008; 105(34): 12569 - 12574. [Abstract] [Full Text] [PDF]

				M. D. Greicius, K. Supekar, V. Menon, and R. F. Dougherty Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Cereb Cortex, April 9, 2008; (2008) bhn059v1. [Abstract] [Full Text] [PDF]

				D. A. Fair, A. L. Cohen, N. U. F. Dosenbach, J. A. Church, F. M. Miezin, D. M. Barch, M. E. Raichle, S. E. Petersen, and B. L. Schlaggar The maturing architecture of the brain's default network PNAS, March 11, 2008; 105(10): 4028 - 4032. [Abstract] [Full Text] [PDF]

				W. W. Seeley, R. Crawford, K. Rascovsky, J. H. Kramer, M. Weiner, B. L. Miller, and M. L. Gorno-Tempini Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia Arch Neurol, February 1, 2008; 65(2): 249 - 255. [Abstract] [Full Text] [PDF]

				P. J. Gianaros, L. K. Sheu, K. A. Matthews, J. R. Jennings, S. B. Manuck, and A. R. Hariri Individual Differences in Stressor-Evoked Blood Pressure Reactivity Vary with Activation, Volume, and Functional Connectivity of the Amygdala J. Neurosci., January 23, 2008; 28(4): 990 - 999. [Abstract] [Full Text] [PDF]

				G.D. Rabinovici, W.W. Seeley, E.J. Kim, M.L. Gorno-Tempini, K. Rascovsky, T.A. Pagliaro, S.C. Allison, C. Halabi, J.H. Kramer, J.K. Johnson, et al. Distinct MRI Atrophy Patterns in Autopsy-Proven Alzheimer's Disease and Frontotemporal Lobar Degeneration American Journal of Alzheimer's Disease and Other Dementias, January 1, 2008; 22(6): 474 - 488. [Abstract] [PDF]

				W. W. Seeley, B. R. Matthews, R. K. Crawford, M. L. Gorno-Tempini, D. Foti, I. R. Mackenzie, and B. L. Miller Unravelling Bolero: progressive aphasia, transmodal creativity and the right posterior neocortex Brain, January 1, 2008; 131(1): 39 - 49. [Abstract] [Full Text] [PDF]

				P. Fransson, B. Skiold, S. Horsch, A. Nordell, M. Blennow, H. Lagercrantz, and U. Aden Resting-state networks in the infant brain PNAS, September 25, 2007; 104(39): 15531 - 15536. [Abstract] [Full Text] [PDF]

				D. A. Fair, N. U. F. Dosenbach, J. A. Church, A. L. Cohen, S. Brahmbhatt, F. M. Miezin, D. M. Barch, M. E. Raichle, S. E. Petersen, and B. L. Schlaggar Development of distinct control networks through segregation and integration PNAS, August 14, 2007; 104(33): 13507 - 13512. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help