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The Journal of Neuroscience, January 2, 2008, 28(1):249-257; doi:10.1523/JNEUROSCI.5514-06.2008

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Development/Plasticity/Repair
Establishment of a Scaffold for Orientation Maps in Primary Visual Cortex of Higher Mammals

Agnieszka Grabska-Barwinska1,2 and Christoph von der Malsburg3

1Institut für Neuroinformatik, Ruhr-Universität Bochum, 44780 Bochum, Germany, 2International Graduate School of Neuroscience, 44780 Bochum, Germany, and 3Frankfurt Institute for Advanced Studies, 60438 Frankfurt am Main, Germany

Correspondence should be addressed to Agnieszka Grabska-Barwinska, Institut für Neuroinformatik Ruhr-Universität, Bochum Building ND, Room 03/31, 44780 Bochum, Germany. Email: Agnieszka.Grabska-Barwinska{at}rub.de

In higher mammals, environmentally driven patterns of neural activity do not play a role in the establishment of orientation specificity and maps. It has been proposed that specific long-range interactions provide the scaffold for developing orientation maps. Our model aims at explaining how such a scaffold could develop in the first place. Broad spontaneous activity waves and locally evoked spatially periodic response pattern are used. The model is discussed in relation to biological evidence, and experiments to test the model are proposed. We show that reliable orientation specificity cannot be a result of haphazard cortical wiring, as has been proposed.

Key words: neonatal prenatal; development; area 17; plasticity; orientation specificity; horizontal connectivity

Received July 26, 2006; revised Nov. 9, 2007; accepted Nov. 26, 2007.

Correspondence should be addressed to Agnieszka Grabska-Barwinska, Institut für Neuroinformatik Ruhr-Universität, Bochum Building ND, Room 03/31, 44780 Bochum, Germany. Email: Agnieszka.Grabska-Barwinska{at}rub.de






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