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The Journal of Neuroscience, March 5, 2008, 28(10):2539-2550; doi:10.1523/JNEUROSCI.5487-07.2008

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Behavioral/Systems/Cognitive
A Hierarchy of Temporal Receptive Windows in Human Cortex

Uri Hasson,^1,2 Eunice Yang,¹ Ignacio Vallines,^3,4 David J. Heeger,^1,2 and Nava Rubin¹

¹Center for Neural Science and ²Department of Psychology, New York University, New York, New York 10003, ³Institute for Experimental Psychology, University of Regensburg, 93053 Regensburg, Germany, and ⁴Department of Experimental Psychology, Ludwig-Maximilian University of Munich, 80539 Munich, Germany

Correspondence should be addressed to Dr. Uri Hasson, Center for Neural Science, New York University, 4 Washington Place, Room 955, New York, NY 10003. Email: uri.hasson{at}nyu.edu

Real-world events unfold at different time scales and, therefore, cognitive and neuronal processes must likewise occur at different time scales. We present a novel procedure that identifies brain regions responsive to sensory information accumulated over different time scales. We measured functional magnetic resonance imaging activity while observers viewed silent films presented forward, backward, or piecewise-scrambled in time. Early visual areas (e.g., primary visual cortex and the motion-sensitive area MT+) exhibited high response reliability regardless of disruptions in temporal structure. In contrast, the reliability of responses in several higher brain areas, including the superior temporal sulcus (STS), precuneus, posterior lateral sulcus (LS), temporal parietal junction (TPJ), and frontal eye field (FEF), was affected by information accumulated over longer time scales. These regions showed highly reproducible responses for repeated forward, but not for backward or piecewise-scrambled presentations. Moreover, these regions exhibited marked differences in temporal characteristics, with LS, TPJ, and FEF responses depending on information accumulated over longer durations (36 s) than STS and precuneus (12 s). We conclude that, similar to the known cortical hierarchy of spatial receptive fields, there is a hierarchy of progressively longer temporal receptive windows in the human brain.

Key words: temporal coding; fMRI; cortex; receptive fields; functional organization; time

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Received March 30, 2007; accepted Dec. 19, 2007.

Correspondence should be addressed to Dr. Uri Hasson, Center for Neural Science, New York University, 4 Washington Place, Room 955, New York, NY 10003. Email: uri.hasson{at}nyu.edu

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