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The Journal of Neuroscience, March 5, 2008, 28(10):2651-2658; doi:10.1523/JNEUROSCI.4781-07.2008
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Behavioral/Systems/Cognitive
Extinction of a Classically Conditioned Response: Red Nucleus and Interpositus
Karla Robleto andRichard F. Thompson University of Southern California, Los Angeles, California 90089
Correspondence should be addressed to Karla Robleto, University of Southern California, 3641 Watt Way, HNB-522, Los Angeles, CA 90089. Email: krobleto{at}usc.edu
It is well established that the cerebellum and its associated circuitry are essential for classical conditioning of the eyeblink response and other discrete motor responses (e.g., limb flexion, head turn, etc.) learned with an aversive unconditioned stimulus. However, brain mechanisms underlying extinction of these responses are still relatively unclear. Behavioral studies have demonstrated extinction to be an active learning process distinct from acquisition. Accordingly, this current understanding of extinction has guided neural studies that have tried to identify possible brain structures that could support this new learning. However, whether extinction engages the same brain sites necessary for acquisition is not yet clear. This poses an overriding problem for understanding brain mechanisms necessary for extinction because such analysis cannot be done without first identifying brain sites and pathways involved in this phenomenon. Equally elusive is the validity of a behavioral theory of extinction that can account for the properties of extinction. In this study, we looked at the involvement of the interpositus and the red nucleus in extinction. Results show that, although inactivation of both nuclei blocks response expression, only inactivation of the interpositus has a detrimental effect on extinction. Moreover, this detrimental effect was completely removed when inactivation of the interpositus was paired with electrical stimulation of the red nucleus. These findings speak to the important role of cerebellar structures in the extinction of discrete motor responses and provide important insight as to the validity of a particular theory of extinction.
Key words: extinction; cerebellum; classical conditioning; learning; eyeblink; red nucleus; interpositus; inferior olive
Received July 11, 2007; revised Dec. 21, 2007; accepted Jan. 19, 2008.
Correspondence should be addressed to Karla Robleto, University of Southern California, 3641 Watt Way, HNB-522, Los Angeles, CA 90089. Email: krobleto{at}usc.edu
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