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The Journal of Neuroscience, April 2, 2008, 28(14):3759-3768; doi:10.1523/JNEUROSCI.4481-07.2008

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Behavioral/Systems/Cognitive
Deconstruction of Spatial Integrity in Visual Stimulus Detected by Modulation of Synchronized Activity in Cat Visual Cortex

Zhiyi Zhou,¹ Melanie R. Bernard,¹ and A. B. Bonds^1,2

¹Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, and ²Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee 37235

Correspondence should be addressed to A. B. Bonds, Department of Electrical Engineering, Vanderbilt University, 255 Featheringill Hall, 400 24th Avenue South, Nashville, TN 37212. Email: ab{at}vuse.vanderbilt.edu

Spatiotemporal relationships among contour segments can influence synchronization of neural responses in the primary visual cortex. We performed a systematic study to dissociate the impact of spatial and temporal factors in the signaling of contour integration via synchrony. In addition, we characterized the temporal evolution of this process to clarify potential underlying mechanisms. With a 10 x 10 microelectrode array, we recorded the simultaneous activity of multiple cells in the cat primary visual cortex while stimulating with drifting sine-wave gratings. We preserved temporal integrity and systematically degraded spatial integrity of the sine-wave gratings by adding spatial noise. Neural synchronization was analyzed in the time and frequency domains by conducting cross-correlation and coherence analyses. The general association between neural spike trains depends strongly on spatial integrity, with coherence in the gamma band (35–70 Hz) showing greater sensitivity to the change of spatial structure than other frequency bands. Analysis of the temporal dynamics of synchronization in both time and frequency domains suggests that spike timing synchronization is triggered nearly instantaneously by coherent structure in the stimuli, whereas frequency-specific oscillatory components develop more slowly, presumably through network interactions. Our results suggest that, whereas temporal integrity is required for the generation of synchrony, spatial integrity is critical in triggering subsequent gamma band synchronization.

Key words: visual cortex; synchrony; coherence; spatial integrity; noise; gamma oscillation

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Received Oct. 1, 2007; revised Jan. 24, 2008; accepted Feb. 26, 2008.

Correspondence should be addressed to A. B. Bonds, Department of Electrical Engineering, Vanderbilt University, 255 Featheringill Hall, 400 24th Avenue South, Nashville, TN 37212. Email: ab{at}vuse.vanderbilt.edu

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