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The Journal of Neuroscience, April 9, 2008, 28(15):4078-4087; doi:10.1523/JNEUROSCI.5338-07.2008

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Behavioral/Systems/Cognitive
Functional Asymmetries in Visual Pathways Carrying S-Cone Signals in Macaque

Chris Tailby,^1 * Samuel G. Solomon,^2 * and Peter Lennie^1,3

¹Center for Neural Science, New York University, New York, New York 10003, ²Bosch Institute and School of Medical Sciences, The University of Sydney, New South Wales, 2006, Australia, and ³Center for Visual Science and the Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York 14627

Correspondence should be addressed to Chris Tailby, National Vision Research Institute of Australia, Department of Optometry and Vision Sciences, University of Melbourne, Corner of Keppel and Cardigan Streets, Carlton, Victoria 3053, Australia. Email: ctailby{at}unimelb.edu.au

In the lateral geniculate nucleus of macaque, we recorded from neurons with substantial input from S-cones and found that, on several important dimensions, the properties of neurons that receive inhibitory input from S-cones ("S–") are quite unlike those of neurons that receive excitatory input from S-cones ("S+"). First, the organization of chromatic inputs differs substantially: in S+ cells, S-cone signals were usually opposed by those of L- and M-cones; in S– cells, signals from L-cones were usually opposed to those of S- and M-cones. Second, to pure S-cone modulation, S+ cells are twice as sensitive as S– cells, but S– cells were much more susceptible to contrast adaptation. Third, in S– cells but not S+ cells, the spatial frequency resolution for achromatic modulation was often greater, the tuning curve and more bandpass, than that for S-cone modulation. Along the dimensions on which we measured, the properties of the S+ cells were relatively tightly clustered, suggesting a homogenous class. Although the chromatic properties of S– cells are heterogeneous, the distribution of their tuning along other stimulus dimensions does not suggest multiple subtypes.

Key words: vision; color; macaque; LGN; parallel pathways; S-cone; blue cone

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Received Aug. 2, 2007; revised March 3, 2008; accepted March 4, 2008.

Correspondence should be addressed to Chris Tailby, National Vision Research Institute of Australia, Department of Optometry and Vision Sciences, University of Melbourne, Corner of Keppel and Cardigan Streets, Carlton, Victoria 3053, Australia. Email: ctailby{at}unimelb.edu.au

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