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The Journal of Neuroscience, April 23, 2008, 28(17):4414-4422; doi:10.1523/JNEUROSCI.0372-08.2008

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Development/Plasticity/Repair
Semaphorin 3F Confines Ventral Tangential Migration of Lateral Olfactory Tract Neurons onto the Telencephalon Surface

Keisuke Ito,¹ Takahiko Kawasaki,¹ Seiji Takashima,² Ikuo Matsuda,³ Atsu Aiba,³ and Tatsumi Hirata¹

¹Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies (Sokendai), Yata 1111, Mishima 411-8540, Japan, ²Health Care Center, Osaka University, Suita, Osaka 565-0871, Japan, and ³Division of Molecular Genetics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan

Correspondence should be addressed to Dr. Tatsumi Hirata, Division of Brain Function, National Institute of Genetics, 1111 Yata, Mishima 411-8540, Japan. Email: tathirat{at}lab.nig.ac.jp

Ventral tangential migration of neurons is the most prominent mode of neuronal translocation during earliest neurogenesis in the mouse telencephalon. A typical example of the neurons that adopt this migration mode is guidepost neurons in the lateral olfactory tract designated as lot cells. These neurons are generated from the neocortical neuroepithelium and migrate tangentially down to the ventral edge of the neocortex abutting the ganglionic eminence, on which the future lateral olfactory tract develops. We show here that this migration stream is repelled by a secreted axon guidance molecule, semaphorin 3F through interaction with its specific receptor, neuropilin-2. Accordingly, in mutant mice for semaphorin 3F or neuropilin-2, lot cells ectopically penetrated into the deep brain domain, which normally expresses semaphorin 3F. These results reveal that semaphorin 3F is an important regulator of the ventral tangential migration stream, confining the migrating neurons on the telencephalon surface by repelling from the deeper domain.

Key words: neuronal migration; semaphorin 3F; neuropilin-2; lateral olfactory tract; lot cell; repulsive guidance

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Received Aug. 27, 2007; revised Feb. 21, 2008; accepted March 17, 2008.

Correspondence should be addressed to Dr. Tatsumi Hirata, Division of Brain Function, National Institute of Genetics, 1111 Yata, Mishima 411-8540, Japan. Email: tathirat{at}lab.nig.ac.jp

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